Rossi Federica, Cancedda Simona, Leone Vito Ferdinando, Rohrer Bley Carla, Laganga Paola
Centro Oncologico Veterinario, Sasso Marconi, Italy.
Clinica Veterinaria dell'Orologio, Sasso Marconi, Italy.
Front Vet Sci. 2018 Apr 10;5:74. doi: 10.3389/fvets.2018.00074. eCollection 2018.
The aim of the study was to evaluate the efficacy and toxicity of a low-dose radiotherapy treatment in dogs with osteoarthritis (OA). Inclusion criteria were dogs affected by OA of one or multiple joints, with lameness, previously treated with medical therapy and referred for radiotherapy because of chronic unresponsive pain. After suspension of medical therapy, dogs underwent external beam radiotherapy treatments delivered in three fractions of 2 Gy each. Four of these dogs had one (three dogs) to four (one dog) additional courses of radiation. Medical records were reviewed and follow-up information was collected by clinical recheck and owners interview. Twenty-five dogs matched the inclusion criteria; among them, 21 had one course of RT and 4 underwent multiple treatments, respectively 218, 266, 39, and 1,384 days after the first treatment. Clinical improvement was observed in 92% of patients with median benefit duration of 356 days after the first treatment, and 418 days after the second treatment. No side effects were recorded. In this group of patients, radiotherapy was effective, well tolerated, and repeatable, leading to an improvement of quality of life in dogs with degenerative joint disease unresponsive to medical treatments.
本研究的目的是评估低剂量放射治疗对骨关节炎（OA）犬的疗效和毒性。纳入标准为患有一个或多个关节OA、跛行、先前接受过药物治疗且因慢性疼痛无反应而转诊接受放射治疗的犬。在暂停药物治疗后，犬接受了每次2 Gy、分三次进行的外照射放射治疗。其中4只犬额外接受了1次（3只犬）至4次（1只犬）放射治疗。回顾医疗记录，并通过临床复查和主人访谈收集随访信息。25只犬符合纳入标准；其中，21只接受了一个疗程的放疗，4只接受了多次治疗，分别在首次治疗后218、266、39和1384天。92%的患者观察到临床改善，首次治疗后中位受益持续时间为356天，第二次治疗后为418天。未记录到副作用。在这组患者中，放射治疗有效、耐受性良好且可重复，可改善对药物治疗无反应的退行性关节病犬的生活质量。
