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全膝关节置换术中持续与单次注射股神经阻滞的有效性:一项双盲随机试验。

Effectiveness of continuous versus single injection femoral nerve block for total knee arthroplasty: A double blinded, randomized trial.

作者信息

Dixit Varun, Fathima Samreen, Walsh Stephen M, Seviciu Alexandru, Schwendt Ivan, Spittler Karl-Heinz, Briggs Dana

机构信息

Department of Anesthesia, Eastern Maine Medical Center, Bangor, ME 04401, USA.

Clinical Research Center, Eastern Maine Medical Center, One Cumberland Place Bangor, ME 04401, USA.

出版信息

Knee. 2018 Aug;25(4):623-630. doi: 10.1016/j.knee.2018.04.001. Epub 2018 Apr 26.

Abstract

BACKGROUND

Effective analgesia following total knee arthroplasty (TKA) is important for maximizing patient satisfaction, early participation in physical therapy and reducing the hospital stay. This trial compared continuous catheter femoral nerve block (cFNB) to single injection femoral nerve block (sFNB) in terms of analgesia, opioid consumption, and participation in physical therapy and associated side effects.

METHODS

This randomized, double blinded trial was conducted in a non-university hospital setting, without major changes to anesthesia or surgical clinical pathways. A total of 85 patients scheduled for primary TKA were randomized to receive either cFNB (n=44) or sFNB (n=41). All patients had FNB with 0.5% ropivacaine bolus followed by subarachnoid block for surgery. Postoperatively, 0.2% ropivacaine infusion was commenced in cFNB group and a sham catheter was taped to the skin in sFNB group. All patients received a structured multimodal analgesia regimen throughout hospital stay. The primary outcomes were peak resting visual analogue scale (VAS) scores and morphine consumption at 48h postoperatively.

RESULTS

VAS scores (Mean difference 0.25, 95% Confidence Interval (CI) -0.56 to 1.06; [P=0.196]) and morphine consumption (Mean difference 0.95mg, 95% CI -9.99 to 11.89; [P=0.863]) were not significantly different among patients who received cFNB versus sFNB at 48h. There was no difference in hospital stay (P=0.517) or long-term functional recovery between the two groups (P=0.385).

CONCLUSIONS

sFNB block provides equal pain relief compared with cFNB, after TKA with no significant difference in opioid consumption, hospital stay, physical therapy outcomes or associated side effects.

摘要

背景

全膝关节置换术(TKA)后有效的镇痛对于提高患者满意度、早期参与物理治疗以及缩短住院时间至关重要。本试验比较了连续导管股神经阻滞(cFNB)与单次注射股神经阻滞(sFNB)在镇痛、阿片类药物消耗、物理治疗参与度及相关副作用方面的差异。

方法

本随机双盲试验在一家非大学医院进行,麻醉或手术临床路径无重大改变。共有85例计划行初次TKA的患者被随机分为cFNB组(n = 44)或sFNB组(n = 41)。所有患者均接受0.5%罗哌卡因推注的股神经阻滞,随后行蛛网膜下腔阻滞用于手术。术后,cFNB组开始输注0.2%罗哌卡因,sFNB组在皮肤上粘贴假导管。所有患者在住院期间均接受结构化多模式镇痛方案。主要结局指标为术后48小时静息时的视觉模拟评分(VAS)峰值和吗啡消耗量。

结果

在术后48小时,接受cFNB与sFNB的患者之间,VAS评分(平均差值0.25,95%置信区间(CI)-0.56至1.06;[P = 0.196])和吗啡消耗量(平均差值0.95mg,95% CI -9.99至11.89;[P = 0.863])无显著差异。两组在住院时间(P = 0.517)或长期功能恢复方面也无差异(P = 0.385)。

结论

在TKA术后,sFNB阻滞与cFNB提供同等的疼痛缓解效果,在阿片类药物消耗、住院时间、物理治疗结局或相关副作用方面无显著差异。

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