N-甲基烷基铵盐受体的鉴定与分离：在伪肽动态组合库中的分子放大
Identification and Isolation of a Receptor for N-Methyl Alkylammonium Salts: Molecular Amplification in a Pseudo-peptide Dynamic Combinatorial Library.
作者信息
Cousins Graham R L, Furlan Ricardo L E, Ng Yiu-Fai, Redman James E, Sanders Jeremy K M
机构信息
Cambridge Centre for Molecular Recognition University Chemical Laboratory, University of Cambridge Lensfield Road, Cambridge, CB2 1EW (UK) Fax: (+44) 1223-336-017.
出版信息
Angew Chem Int Ed Engl. 2001 Jan 19;40(2):423-428. doi: 10.1002/1521-3773(20010119)40:2<423::AID-ANIE423>3.0.CO;2-6.
A cyclic pseudo-peptide receptor for acetylcholine has been amplified and isolated from a dynamic combinatorial library by virtue of templated stabilization under thermodynamic control (see scheme, TFA=trifluoroacetic acid). This is a demonstration of significant molecular amplification in dynamic systems to evolve a novel receptor.
一种用于乙酰胆碱的环状假肽受体已通过在热力学控制下的模板稳定作用从动态组合库中扩增并分离出来（见示意图，TFA = 三氟乙酸）。这证明了动态系统中显著的分子扩增以进化出一种新型受体。
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