SET-9 和 SET-26 是 H3K4me3 的阅读器，在生殖细胞发育和寿命中发挥关键作用。
SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity.
机构信息
Department of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Computational Biology Service Unit, Cornell University, Ithaca, United States.
出版信息
Elife. 2018 May 1;7:e34970. doi: 10.7554/eLife.34970.
SET-9 and SET-26 are highly homologous paralogs that share redundant functions in germline development, but SET-26 alone plays a key role in longevity and heat stress response. Whereas SET-26 is broadly expressed, SET-9 is only detectable in the germline, which likely accounts for their different biological roles. SET-9 and SET-26 bind to H3K4me3 with adjacent acetylation marks in vitro and in vivo. In the soma, SET-26 acts through DAF-16 to modulate longevity. In the germline, SET-9 and SET-26 restrict H3K4me3 domains around SET-9 and SET-26 binding sites, and regulate the expression of specific target genes, with critical consequence on germline development. SET-9 and SET-26 are highly conserved and our findings provide new insights into the functions of these H3K4me3 readers in germline development and longevity.
SET-9 和 SET-26 是高度同源的旁系同源物，它们在生殖细胞发育中具有冗余功能，但 SET-26 单独在长寿和热应激反应中发挥关键作用。虽然 SET-26 广泛表达，但 SET-9 仅在生殖细胞中检测到，这可能解释了它们不同的生物学作用。SET-9 和 SET-26 在体外和体内与 H3K4me3 结合，带有相邻的乙酰化标记。在体细胞中，SET-26 通过 DAF-16 发挥作用，调节寿命。在生殖细胞中，SET-9 和 SET-26 限制 SET-9 和 SET-26 结合位点周围的 H3K4me3 结构域，并调节特定靶基因的表达，对生殖细胞发育有重要影响。SET-9 和 SET-26 高度保守，我们的发现为这些 H3K4me3 读取器在生殖细胞发育和长寿中的功能提供了新的见解。
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