帕米膦酸对犬拔牙窝牙槽骨的抗吸收作用。
Anti-resorptive effect of pamidronate on extraction socket wall in dogs.
机构信息
Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea.
Department of Periodontology, Faculty of Odontology, Complutense University of Madrid, Madrid, Spain.
出版信息
Clin Oral Implants Res. 2018 Jul;29(7):688-696. doi: 10.1111/clr.13260. Epub 2018 May 12.
AIM
The aim of this experimental in vivo investigation was to assess the anti-resorptive effect of low concentration pamidronate on the buccal plate in fresh extraction sockets.
MATERIALS AND METHODS
The distal roots of the third premolars were extracted bilaterally in six dogs. A collagen matrix loaded with either pamidronate (test group) or saline (control group) was positioned on the outer surface of buccal bone immediately after tooth extraction and subsequently covered with a coronally advanced flap. Histological and histomorphometric outcomes were evaluated 12 weeks later.
RESULTS
The mean vertical distance between the buccal and lingual bone crest differed significantly between the test and control groups (0.52 ± 0.43 and 2.21 ± 1.15 mm, respectively; p = .037). The width of the buccal bone 1 mm below the crest was significantly wider in the test group than the control group (4.68 ± 0.68 vs. 3.44 ± 0.60 mm, p < .001).
CONCLUSIONS
Local application of pamidronate onto a collagen matrix may reduce the dimensional changes of the buccal bone plate both vertically and horizontally.
目的
本体内实验研究旨在评估低浓度帕米膦酸盐对新鲜拔牙窝颊板的抗吸收作用。
材料和方法
将 6 只狗的第三磨牙的远根双侧拔出。在拔牙后立即将载有帕米膦酸盐（实验组）或生理盐水（对照组）的胶原基质置于颊骨的外表面，随后用冠向推进瓣覆盖。12 周后评估组织学和组织形态计量学结果。
结果
实验组和对照组颊侧和舌侧牙槽嵴之间的平均垂直距离差异有统计学意义（分别为 0.52 ± 0.43 和 2.21 ± 1.15mm；p = 0.037）。实验组颊侧骨嵴下方 1mm 处的颊骨宽度明显大于对照组（分别为 4.68 ± 0.68 和 3.44 ± 0.60mm；p < 0.001）。
结论
将帕米膦酸盐局部应用于胶原基质上可能会减少颊板在垂直和水平方向上的尺寸变化。
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