Brown Matthew S, Ashley Brandon, Koh Ahyeon
Department of Biomedical Engineering, State University of New York at Binghamton University, Binghamton, NY, United States.
Front Bioeng Biotechnol. 2018 Apr 26;6:47. doi: 10.3389/fbioe.2018.00047. eCollection 2018.
Chronic non-healing wounds challenge tissue regeneration and impair infection regulation for patients afflicted with this condition. Next generation wound care technology capable of physiological surveillance which can diagnose wound parameters, treat various chronic wound symptoms, and reduce infection at the wound noninvasively with the use of a closed loop therapeutic system would provide patients with an improved standard of care and an accelerated wound repair mechanism. The indicating biomarkers specific to chronic wounds include blood pressure, temperature, oxygen, pH, lactate, glucose, interleukin-6 (IL-6), and infection status. A wound monitoring device would help decrease prolonged hospitalization, multiple doctors' visits, and the expensive lab testing associated with the diagnosis and treatment of chronic wounds. A device capable of monitoring the wound status and stimulating the healing process is highly desirable. In this review, we discuss the impaired physiological states of chronic wounds and explain the current treatment methods. Specifically, we focus on improvements in materials, platforms, fabrication methods for wearable devices, and quantitative analysis of various biomarkers vital to wound healing progress.
慢性难愈合伤口对组织再生构成挑战，并损害患有这种疾病的患者的感染调节能力。能够进行生理监测的下一代伤口护理技术，可诊断伤口参数、治疗各种慢性伤口症状，并通过使用闭环治疗系统以非侵入方式减少伤口感染，这将为患者提供更高的护理标准和加速伤口修复机制。慢性伤口特有的指示性生物标志物包括血压、温度、氧气、pH值、乳酸、葡萄糖、白细胞介素-6（IL-6）和感染状态。伤口监测设备将有助于减少长期住院、多次就医以及与慢性伤口诊断和治疗相关的昂贵实验室检测。一种能够监测伤口状态并刺激愈合过程的设备是非常需要的。在这篇综述中，我们讨论了慢性伤口受损的生理状态，并解释了当前的治疗方法。具体而言，我们重点关注可穿戴设备在材料、平台、制造方法方面的改进，以及对伤口愈合进展至关重要的各种生物标志物的定量分析。
