散发性结直肠癌中 DNA 修复的临床重要性。

Clinical importance of DNA repair in sporadic colorectal cancer.

机构信息

Surgical Oncology Service, Santa Casa de Misericórdia de Porto Alegre (ISCMPA), Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil.

Institute of Cardiology/University Foundation of Cardiology, Porto Alegre, Rio Grande do Sul, Brazil; Laboratory of Genetic Toxicology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil.

出版信息

Crit Rev Oncol Hematol. 2018 Jun;126:168-185. doi: 10.1016/j.critrevonc.2018.03.017. Epub 2018 Mar 29.

DOI:10.1016/j.critrevonc.2018.03.017

PMID:29759559

Abstract

Colorectal cancer (CRC) is the third major cause of cancer-related deaths worldwide. However, despite the scientific efforts to provide a molecular classification to improve CRC clinical practice management, prognosis and therapeutic decision are still strongly dependent on the TNM staging system. Mismatch repair system deficiencies can occur in many organs, but it is mainly a hallmark of CRC influencing clinical outcomes and response to therapy. This review will discuss the effect of the modulation of other DNA repair pathways (direct, excision and double strand break repairs) in the clinical and pathological aspects of colorectal cancer and its potential as prognostic and predictive biomarkers.

摘要

结直肠癌（CRC）是全球癌症相关死亡的第三大主要原因。然而，尽管科学界努力提供分子分类以改善 CRC 的临床实践管理，但预后和治疗决策仍然强烈依赖于 TNM 分期系统。错配修复系统缺陷可能发生在许多器官中，但它主要是影响 CRC 临床结果和对治疗反应的标志。这篇综述将讨论其他 DNA 修复途径（直接修复、切除修复和双链断裂修复）的调节在结直肠癌的临床和病理方面的作用及其作为预后和预测生物标志物的潜力。