非酒精性脂肪性肝病：诊断的最新进展
Non-alcoholic fatty liver disease: an update on diagnosis.
作者信息
Dumitrascu Dan L, Neuman Manuela G
机构信息
Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
In Vitro Drug Safety and Biotechnology; Toronto, Ontario, Canada.
出版信息
Clujul Med. 2018;91(2):147-150. doi: 10.15386/cjmed-993. Epub 2018 Apr 25.
Abstract
BACKGROUND AND AIM
The non-alcoholic fatty liver disease (NAFLD) and its sub-entity, the non-alcoholic steatohepatitis (NASH) represent a field of a tremendous progress in recent years. Clinicians need to remain updated with new data on pathogenesis and therapy. The present mini review aims to present some new scientific reports on the diagnosis of NAFLD and NASH for clinical practitioners.
METHODS
A systematic literature search of the main international databases was performed. We looked for seminal and innovative papers published in main international languages. A narrative review of the topic was consequently written.
RESULTS
This review describes new data on the diagnosis of NAFLD including NASH. Liver punction biopsy remains the gold standard. However many patients and clinicians prefer to use noninvasive methods. We present the serological tests and the imaging methods used to diagnose inflammation and fibrosis occurring in NAFLD and NASH.
CONCLUSIONS
NAFLD-NASH are multifaceted entities that have to be diagnosed and treated by skilled and informed practitioners.
摘要
背景与目的
非酒精性脂肪性肝病（NAFLD）及其子类型非酒精性脂肪性肝炎（NASH）是近年来取得巨大进展的一个领域。临床医生需要不断了解有关发病机制和治疗的新数据。本综述旨在为临床医生介绍一些关于NAFLD和NASH诊断的新科学报告。
方法
对主要国际数据库进行系统的文献检索。我们查找了以主要国际语言发表的开创性和创新性论文。随后撰写了该主题的叙述性综述。
结果
本综述描述了包括NASH在内的NAFLD诊断的新数据。肝穿刺活检仍然是金标准。然而，许多患者和临床医生更喜欢使用非侵入性方法。我们介绍了用于诊断NAFLD和NASH中发生的炎症和纤维化的血清学检测和成像方法。
结论
NAFLD - NASH是多方面的疾病，必须由经验丰富且知识渊博的医生进行诊断和治疗。
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