Nordin Viviann, Olsson Ingrid B, Tomson Torbjörn
Karolinska Institutet Department of Women's and Children's Health - Stockholm, Sweden Karolinska Institutet Department of Women's and Children's Health - Stockholm, Sweden.
Avdelningen för pediatrik, Institutionen för kliniska vetenskaper, Sahlgrenska akademin vid Göteborgs Universitet - Göteborg, Sweden.
Lakartidningen. 2018 May 22;115:E47E.
In children and adults with epilepsy, it is important to be aware of and diagnose common comorbidities that may have a large impact on quality of life. Comorbid neurodevelopmental disorders include intellectual disability, autism, and attention deficit hyperactivity disorder (ADHD). Depression and anxiety are common findings, and also the risk of psychosis is increased. The medication used to treat these comorbidities is found to be effective with little risks of seizure exacerbation, i.e. medication with methylphenidate, selective serotonin reuptake inhibitors (SSRIs) and second generation neuroleptics. However, for every combination of antiepileptic drugs with new medication, the possibility of drug interactions should be kept in mind. Transition from childhood to adult medicine must include adequate treatment and follow-up of comorbid conditions.
对于患有癫痫的儿童和成人,认识并诊断可能对生活质量产生重大影响的常见共病很重要。共病的神经发育障碍包括智力残疾、自闭症和注意力缺陷多动障碍(ADHD)。抑郁和焦虑很常见,而且患精神病的风险也会增加。用于治疗这些共病的药物被发现有效,且癫痫发作加剧的风险很小,即使用哌甲酯、选择性5-羟色胺再摄取抑制剂(SSRI)和第二代抗精神病药物。然而,对于每种抗癫痫药物与新药的组合,都应牢记药物相互作用的可能性。从儿童用药过渡到成人用药必须包括对共病状况的充分治疗和随访。