警察亚临床心血管疾病标志物：皮质醇觉醒反应和血流介导的动脉扩张的纵向评估。
Subclinical Markers of Cardiovascular Disease Among Police Officers: A Longitudinal Assessment of the Cortisol Awakening Response and Flow Mediated Artery Dilation.
机构信息
Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, the State University of New York, Buffalo, New York (Dr Violanti); Biostatistics and Epidemiology Branch (Dr Fekedulegn, Dr Andrew, Dr Charles, and Mr Gu); Toxicology and Molecular Biology Branch (Dr Miller), Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.
出版信息
J Occup Environ Med. 2018 Sep;60(9):853-859. doi: 10.1097/JOM.0000000000001358.
OBJECTIVE
To examine the association of the cortisol awakening response (CAR) with change in brachial artery flow-mediated dilation (FMD%) in police officers over a 7-year period.
METHODS
Baseline CAR was obtained from four saliva samples taken 15 minutes apart immediately after awakening. Analysis of covariance was used to compare the change in FMD% (FMD%Follow-up-FMD%Baseline) across tertiles of area under the cortisol curve with respect to increase (AUCI). Regression analysis was use to assess trend.
RESULTS
Officers (n = 172; 81% men) had a mean ± SD age of 41 ± 7.6 years. Men in the lowest AUCI tertile (ie, atypical waking cortisol pattern) had a significantly larger 7-year mean decline in FMD% (mean ± SE: -2.56 ± 0.64) compared with men in the highest tertile (-0.89 ± 0.69) (P = 0.0087).
CONCLUSIONS
An awakening cortisol AUCI predicted worsening of FMD% approximately 7 years later among male officers.
目的
考察皮质醇觉醒反应（CAR）与警察在 7 年内肱动脉血流介导扩张（FMD%）变化的关系。
方法
在觉醒后立即间隔 15 分钟采集 4 个唾液样本以获得基线 CAR。使用协方差分析比较了皮质醇曲线下面积与增加（AUCI）相对应的三分位数之间 FMD%变化（FMD%随访-FMD%基线）。使用回归分析评估趋势。
结果
警察（n=172；81%为男性）的平均年龄为 41±7.6 岁。最低 AUCI 三分位组（即不典型觉醒皮质醇模式）的男性，7 年内 FMD%的平均下降幅度明显大于最高三分位组（-2.56±0.64 对-0.89±0.69）（P=0.0087）。
结论
唤醒时皮质醇 AUCI 预测了大约 7 年后男性警察的 FMD%恶化。
Zotero 插件