Bansal Saurabh, Das Kunal, Jain Navneet, Nautiyal Vipul, Gupta Meenu, Shirazi Nadia, Verma Sanjiv, Ahmad Mushtaq, Saini Sunil
Department of Radiotherapy, Cancer Research Institute, SRHU, Dehradun, Uttarakhand, India.
Department of Medical Oncology & Hematology, Cancer Research Institute, SRHU, Dehradun, Uttarakhand, India.
Sarcoma. 2018 Apr 1;2018:4350634. doi: 10.1155/2018/4350634. eCollection 2018.
The most common site for soft tissue sarcoma is extremity. As complete surgical resection is possible in majority, outcome of this subset is relatively better. There is paucity of data regarding extremity soft tissue sarcoma (STS) from sub-Himalayan and hilly geographical regions.
Retrospective analysis was done for extremity STS visiting the study center over a period of 5 years. Data were collected and analyzed for demography, disease characteristics, treatment modalities, and outcome.
Extremity STS constituted 32.8% of all STS enlisted. Most common subtype noted was pleomorphic STS. Metastatic disease at presentation was noted among 7/43 cases with lung being the most common metastasis site. Wide local excision was done in 37 cases while amputation was required in 5 cases. Adjuvant radiotherapy was given in 27 cases while 18 cases received adjuvant chemotherapy. At median follow-up of 47 months, the overall survival and event-free survival were noted as 47.64% and 41.49%, respectively.
This study depicts single-center experience of extremity STS. The population analyzed was from sub-Himalayan region with significant lost to follow-up. Pooling of data from different centers has been advocated to derive conclusive results.
软组织肉瘤最常见的部位是四肢。由于大多数情况下可以进行完整的手术切除,这一亚组的预后相对较好。来自喜马拉雅山以南和山区地理区域的关于四肢软组织肉瘤(STS)的数据较少。
对在5年期间就诊于研究中心的四肢STS进行回顾性分析。收集并分析了人口统计学、疾病特征、治疗方式和预后的数据。
四肢STS占所有登记的STS的32.8%。最常见的亚型是多形性STS。在43例病例中有7例在就诊时出现转移性疾病,肺是最常见的转移部位。37例进行了广泛局部切除,5例需要截肢。27例接受了辅助放疗,18例接受了辅助化疗。在中位随访47个月时,总生存率和无事件生存率分别为47.64%和41.49%。
本研究描述了四肢STS的单中心经验。所分析的人群来自喜马拉雅山以南地区,随访中有大量失访。提倡汇总不同中心的数据以得出结论性结果。