Block M S, Kent J N
J Oral Maxillofac Surg. 1985 Jan;43(1):3-7. doi: 10.1016/s0278-2391(85)80005-7.
Dog mandibles were augmented with either hydroxylapatite (HA) alone or HA combined with autogenous bone. Within the limited time frame of this experiment (16 weeks) the group which received HA alone did not demonstrate the induction of bony ingrowth further than 1-2 mm into the augmented ridge. However, the animals augmented with HA combined with autogenous bone demonstrated an active, lamellar-type bony ingrowth, maturing bony haversian systems, and vascular elements forming throughout the entire area, extending to the overlying soft tissue interface. The clinical assessment of both types of augmented ridges (HA and HA and bone) were similar; both formed hard, firm ridges at approximately the same rate. This observation is consistent with human clinical experience with HA or HA mixed with bone. However,for patients who have severe mandibular atrophy and for whom increased mandibular bony bulk is crucial, a combination of HA and bone should be advantageous because of the increased extent of bony ingrowth.
犬下颌骨分别用单独的羟基磷灰石(HA)或HA与自体骨联合进行增强。在本实验的有限时间范围内(16周),仅接受HA的组在增强嵴内骨向内生长的诱导深度不超过1 - 2毫米。然而,用HA与自体骨联合增强的动物表现出活跃的板层状骨向内生长、成熟的骨哈弗斯系统以及在整个区域形成的血管成分,并延伸至上覆软组织界面。两种类型增强嵴(HA以及HA与骨联合)的临床评估相似;两者以大致相同的速率形成坚硬、坚实的嵴。这一观察结果与人类使用HA或HA与骨混合的临床经验一致。然而,对于患有严重下颌骨萎缩且增加下颌骨骨量至关重要的患者,HA与骨联合使用应具有优势,因为骨向内生长的范围更大。