母体和新生儿针对特定肠道病毒的中和抗体滴度。

Maternal and neonatal neutralizing antibody titers to selected enteroviruses.

作者信息

Hammond G W, Lukes H, Wells B, Thompson L, Low D E, Cheang M

出版信息

Pediatr Infect Dis. 1985 Jan-Feb;4(1):32-5. doi: 10.1097/00006454-198501000-00009.

DOI:10.1097/00006454-198501000-00009

Abstract

Neutralizing antibody titers were determined at term for 98 matched mothers' serum and neonatal cord blood pairs, to coxsackieviruses B2, B3, B4 and B5 and to echovirus 11. The reciprocal of the geometric mean titers of maternal sera were, respectively, 15.3, 18.1, 53.5, 14.1 and 11.4. The geometric mean titers of cord sera were statistically lower for coxsackie B5 and echovirus 11 (P less than 0.031 and p less than 0.005, respectively) than those in maternal sera. The percentage of neonates born with antibody titers less than 1:10 to coxsackieviruses B2, B3, B4 and B5 and echovirus 11 ere 49, 37, 17, 53 and 69%. Thus a large percentage of neonates in our community are born with low titers of enterovirus-neutralizing antibody, which for some infants may be disproportionately lower than maternal titers to selected enteroviruses. Commercially available immune serum globulin contains high titers of antibody to these enteroviruses and may be a useful means of passive antibody acquisition in susceptible neonates at risk for enterovirus infections. However, a single dose of immune serum globulin intramuscularly produced little change in circulating neutralizing antibodies to coxsackie B4 and echovirus 11 in seven neonates.

摘要

测定了98对配对的母亲血清和新生儿脐带血对柯萨奇病毒B2、B3、B4和B5以及埃可病毒11的中和抗体滴度。母亲血清几何平均滴度的倒数分别为15.3、18.1、53.5、14.1和11.4。脐带血清中柯萨奇B5和埃可病毒11的几何平均滴度在统计学上低于母亲血清中的滴度（分别为P<0.031和P<0.005）。出生时针对柯萨奇病毒B2、B3、B4和B5以及埃可病毒11抗体滴度低于1:10的新生儿百分比分别为49%、37%、17%、53%和69%。因此，我们社区中有很大比例的新生儿出生时肠道病毒中和抗体滴度较低，对于一些婴儿来说，其滴度可能比母亲针对某些肠道病毒的滴度低得不成比例。市售免疫血清球蛋白含有高滴度的针对这些肠道病毒的抗体，可能是有肠道病毒感染风险的易感新生儿被动获得抗体的一种有用方法。然而，对7名新生儿肌内注射单剂量免疫血清球蛋白后，其循环中针对柯萨奇B4和埃可病毒11的中和抗体几乎没有变化。