Department of Chemistry & Institutes of Biomedical Sciences & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai, 200433, China.
Nat Commun. 2018 Jun 5;9(1):2176. doi: 10.1038/s41467-018-04571-4.
Combinational administration of chemotherapy (CT) and photothermal therapy (PTT) has been widely used to treat cancer. However, the scheduling of CT and PTT and how it will affect the therapeutic efficacy has not been thoroughly investigated. The challenge is to realize the sequence control of these two therapeutic modes. Herein, we design a temperature sensitive upconversion nanocomposite for CT-PTT combination therapy. By monitoring the microscopic temperature of the nanocomposite with upconversion luminescence, photothermal effect can be adjusted to achieve thermally triggered combination therapy with a sequence of CT, followed by PTT. We find that CT administered before PTT results in better therapeutic effect than other administration sequences when the dosages of chemodrug and heat are kept at the same level. This work proposes a programmed method to arrange the process of combination cancer therapy, which takes full advantage of each therapeutic mode and contributes to the development of new cancer therapy strategies.
联合化疗（CT）和光热疗法（PTT）已被广泛用于治疗癌症。然而，CT 和 PTT 的治疗方案以及它们将如何影响治疗效果尚未得到彻底研究。挑战在于实现这两种治疗模式的顺序控制。在此，我们设计了一种用于 CT-PTT 联合治疗的温度敏感上转换纳米复合材料。通过上转换发光监测纳米复合材料的微观温度，可以调整光热效应，以实现具有 CT 顺序的热触发联合治疗，随后进行 PTT。我们发现，在保持化学药物和热量剂量相同的情况下，与其他给药顺序相比，PTT 前进行 CT 给药的治疗效果更好。这项工作提出了一种程序化的方法来安排联合癌症治疗的过程，充分利用了每种治疗模式，有助于开发新的癌症治疗策略。
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