Peng Junya, Wang Wenqian, Hua Surong, Liu Lulu
Department of Center Lab, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.
School of Medicine, Tsinghua University, Beijing, China.
Breast Cancer (Auckl). 2018 Apr 25;12:1178223418767666. doi: 10.1177/1178223418767666. eCollection 2018.
Cells can secrete extracellular vesicles (EVs) to communicate with neighboring or distant cells by EVs which are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins, lipids, and nucleic acids. Breast Cancer is the most frequently diagnosed malignancy with more than 1 million new cases each year and ranks the leading cause of cancer mortality in women worldwide. In this review, we will discuss recent progresses of the roles and mechanisms of cancer-derived EVs in metastatic breast cancer, with a special attention on tumor microenvironment construction, progression, and chemo/radiotherapy responses. This review also covers EV roles as biomarker and therapeutic target in clinical application.
细胞能够分泌细胞外囊泡(EVs),通过由包含跨膜蛋白的脂质双层组成并包裹细胞溶质蛋白、脂质和核酸的EVs与邻近或远处的细胞进行通讯。乳腺癌是最常被诊断出的恶性肿瘤,每年有超过100万新病例,是全球女性癌症死亡的主要原因。在本综述中,我们将讨论癌症衍生的EVs在转移性乳腺癌中的作用和机制的最新进展,特别关注肿瘤微环境的构建、进展以及化疗/放疗反应。本综述还涵盖了EVs在临床应用中作为生物标志物和治疗靶点的作用。