Palladium(II)/N-Heterocyclic Carbene Catalyzed One-Pot Sequential α-Arylation/Alkylation: Access to 3,3-Disubstituted Oxindoles.

作者信息

Reddy Panyam Pradeep Kumar, Ugale Bharat, Gandhi Thirumanavelan

机构信息

Department of Chemistry, School of Advanced Sciences , VIT University , Vellore 632014 , India.

Department of Chemistry , Indian Institute of Technology Ropar , Rupnagar , Punjab 140001 , India.

出版信息

J Org Chem. 2018 Aug 3;83(15):7622-7632. doi: 10.1021/acs.joc.8b00264. Epub 2018 Jul 2.

Rationally designed fluorene-based mono- and bimetallic Pd-PEPPSI complexes were synthesized and demonstrated to be effective for the one-pot sequential α-arylation/alkylation of oxindoles. This streamlined approach offers efficient access to functionalized 3,3-disubstituted oxindoles in excellent yields (up to 89%) under mild reaction conditions.