当葡萄糖耗尽时，溶酶体质子泵会开启。
A lysosomal proton pump turns on when glucose runs out.
机构信息
From the Department of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131
From the Department of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131.
出版信息
J Biol Chem. 2018 Jun 8;293(23):9124-9125. doi: 10.1074/jbc.H118.002950.
Abstract
Vacuolar H-ATPase (V-ATPase) is a glucose-responsive, ATP-driven proton pump that controls the acidity of cellular organelles. Increases in glucose stimulate V-ATPase assembly and activity, and glucose deprivation triggers rapid V-ATPase disassembly and inactivation in yeast. McGuire and Forgac describe the opposite phenomenon in mammalian cells, specifically that V-ATPase assembly and activation increases when glucose is lost, raising new questions about mammalian mechanisms of energy conservation.
摘要
液泡型 H+-ATP 酶（V-ATPase）是一种葡萄糖响应的、ATP 驱动的质子泵，可控制细胞细胞器的酸度。葡萄糖的增加会刺激 V-ATPase 的组装和活性，而葡萄糖剥夺会触发酵母中 V-ATPase 的快速解体和失活。McGuire 和 Forgac 描述了哺乳动物细胞中相反的现象，即当葡萄糖丢失时 V-ATPase 的组装和激活增加，这引发了关于哺乳动物能量守恒机制的新问题。
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