早产儿舒张早期功能障碍与呼吸发病率：一项观察性研究。

Early diastolic dysfunction and respiratory morbidity in premature infants: an observational study.

机构信息

Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.

National Children's Research Centre, Dublin, Ireland.

出版信息

J Perinatol. 2018 Sep;38(9):1205-1211. doi: 10.1038/s41372-018-0147-2. Epub 2018 Jun 11.

DOI:10.1038/s41372-018-0147-2

PMID:29887608

Abstract

OBJECTIVE

To test if diastolic dysfunction measured on day one of age is associated with the need for invasive ventilation in preterm infants.

STUDY DESIGN

We conducted a retrospective observational tissue Doppler echocardiographic study over the first 12 h of age for infants born <32 weeks who were invasively ventilated, and infants on continuous positive pressure ventilation (CPAP).

RESULTS

One hundred and eighty-three infants were included (27 ± 2 weeks and 999 ± 296 g). Invasively ventilated infants [(n = 96 (53%)] had lower left ventricular (LV) e' (3.4 ± 1.0 vs. 4.1 ± 1.5 cm/s, p < 0.01) and lower LV ea' ratio (0.8 ± 0.2 vs. 1.0 ± 0.4, p < 0.01), even after adjusting for common neonatal confounders (LV e' adjusted OR 0.62, 95% CI 0.45 - 0.87, p < 0.01; LV ea' adjusted OR 0.14, 95% CI 0.03-0.68, p = 0.01).

CONCLUSION

LV diastolic dysfunction is independently associated with a higher risk for invasive ventilation on day one of age.

摘要

目的

检测婴儿出生后第 1 天的舒张功能障碍是否与早产儿需要有创通气相关。

研究设计

我们对胎龄＜32 周且需有创通气的婴儿以及持续气道正压通气（CPAP）的婴儿进行了组织多普勒超声心动图的回顾性观察研究，检查时间在出生后 12 小时内。

结果

共纳入 183 名婴儿（胎龄 27±2 周，体重 999±296g）。与接受有创通气的婴儿相比，接受有创通气的婴儿左心室（LV）e'波（3.4±1.0 vs. 4.1±1.5cm/s，p<0.01）和 LVea'比值（0.8±0.2 vs. 1.0±0.4，p<0.01）更低，即使在调整了常见的新生儿混杂因素后也是如此（LV e'调整后的 OR 0.62，95%CI 0.45-0.87，p<0.01；LV ea'调整后的 OR 0.14，95%CI 0.03-0.68，p=0.01）。