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中国一名感染甲型禽流感(H9N2)病毒幼儿的临床及流行病学特征

Clinical and epidemiological characteristics of a young child infected with avian influenza A (H9N2) virus in China.

作者信息

Liu Ruchun, Zhao Bin, Li Yelan, Zhang Xixing, Chen Shuilian, Chen Tianmu

机构信息

1 Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.

2 State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, People's Republic of China.

出版信息

J Int Med Res. 2018 Aug;46(8):3462-3467. doi: 10.1177/0300060518779959. Epub 2018 Jun 13.

Abstract

Three cases of the avian influenza A (H9N2) virus have been documented in Changsha, which is a large city that has nine districts and a population of 7.04 million in central South China. Among these patients, one was a girl and two were boys. The ages of the patients were 9 months, 2 years, and 15 years. Two cases of H9N2 were detected in September, 2015 and one was detected in 2017. Two patients were children who had not reached the age for kindergarten and one was a student. These three cases were all mild and were detected in a sentinel hospital of the Chinese Influenza Surveillance System. We describe the clinical and epidemiological features of the youngest patient with H9N2 in 2017 and the surveillance results of the H9N2 virus in live poultry markets in Changsha. From January 2014 to December 2017, 4212 samples were collected in live poultry markets in Changsha, among which 25.81% (1087/4212) were H9N2-positive. Public health concerns should be addressed for emerging H9N2 virus infection, and more strategies should be performed before this virus mutates to be more transmissible and highly pathogenic.

摘要

中国中部的大城市长沙已记录了3例甲型H9N2禽流感病毒感染病例。长沙有9个区,人口704万。这些患者中,1名是女孩,2名是男孩。患者年龄分别为9个月、2岁和15岁。2015年9月检测到2例H9N2病例,2017年检测到1例。2名患者是未到上幼儿园年龄的儿童,1名是学生。这3例病情均较轻,在中国流感监测系统的一家哨点医院被发现。我们描述了2017年最年轻的H9N2患者的临床和流行病学特征以及长沙活禽市场H9N2病毒的监测结果。2014年1月至2017年12月,长沙活禽市场采集了4212份样本,其中25.81%(1087/4212)H9N2呈阳性。对于新出现的H9N2病毒感染应关注公共卫生问题,在该病毒变异为更具传播性和高致病性之前应采取更多策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa23/6134662/ad900e9e9307/10.1177_0300060518779959-fig1.jpg

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