The Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Physics, Auckland, 1142, New Zealand.
Sci Rep. 2018 Jun 18;8(1):9244. doi: 10.1038/s41598-018-27552-5.
Optical Coherence Tomography (OCT) was originally conceived as a volumetric imaging method. Quickly, OCT images went beyond structural data and started to provide functional information about an object enabling for example visualization of blood flow or tissue elasticity. Minimal or no need for system alterations make functional OCT techniques useful in performing multimodal imaging, where differently contrasted images are produced in a single examination. We propose a method that further extends the current capabilities of OCT and requires no modifications to the system. Our algorithm provides information about the sample's Group Velocity Dispersion (GVD) and can be easily applied to any OCT dataset acquired with a Fourier domain system. GVD is calculated from the difference in material's optical thickness measured from two images obtained for different spectral ranges. Instead of using two separate light sources, we propose to apply a filter-based, numerical procedure that synthesizes two spectra from one broadband spectrum. We discuss the limitations of the method and present GVD values for BK7 and sapphire and ocular media: cornea and aqueous humour of a rat eye. Results corroborate previous measurements using two different light sources.
光学相干断层扫描(OCT)最初被设想为一种体积成像方法。很快,OCT 图像超越了结构数据,并开始提供有关物体的功能信息,例如可视化血流或组织弹性。功能 OCT 技术最小化或无需系统更改,使其可用于执行多模态成像,其中在单次检查中产生不同对比度的图像。我们提出了一种进一步扩展当前 OCT 能力的方法,并且不需要对系统进行任何修改。我们的算法提供了有关样品群速度色散(GVD)的信息,并且可以轻松应用于使用傅里叶域系统获取的任何 OCT 数据集。GVD 是通过从两个不同光谱范围获得的两个图像测量的材料光学厚度之间的差异计算得出的。我们建议应用基于滤波器的数值程序,而不是使用两个单独的光源,从一个宽带光谱中合成两个光谱。我们讨论了该方法的局限性,并给出了 BK7 和蓝宝石以及眼部介质:大鼠眼睛的角膜和房水的 GVD 值。结果与使用两种不同光源的先前测量结果相符。