病毒特异性合成肽诱导甲型肝炎病毒中和抗体
Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.
作者信息
Emini E A, Hughes J V, Perlow D S, Boger J
出版信息
J Virol. 1985 Sep;55(3):836-9. doi: 10.1128/JVI.55.3.836-839.1985.
Abstract
Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.
摘要
对甲型肝炎病毒（HAV）和1型脊髓灰质炎病毒的VP1序列进行比较表面特征分析，使得这两个序列得以比对，并确定了可能的HAV中和抗原位点。包含其中一个位点的HAV特异性氨基酸序列的合成肽可诱导抗HAV中和抗体。得出的结论是，尽管一级序列保守性极低，但这两种病毒之间存在结构同源性。
相似文献
1
Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.病毒特异性合成肽诱导甲型肝炎病毒中和抗体
J Virol. 1985 Sep;55(3):836-9. doi: 10.1128/JVI.55.3.836-839.1985.
2
Immunogenicity and antigenicity of chimeric picornaviruses which express hepatitis A virus (HAV) peptide sequences: evidence for a neutralization domain near the amino terminus of VP1 of HAV.表达甲型肝炎病毒（HAV）肽序列的嵌合微小核糖核酸病毒的免疫原性和抗原性：HAV的VP1氨基末端附近存在中和结构域的证据
Virology. 1992 May;188(1):285-95. doi: 10.1016/0042-6822(92)90758-h.
3
Isolation and immunizations with hepatitis A viral structural proteins: induction of antiprotein, antiviral, and neutralizing responses.甲型肝炎病毒结构蛋白的分离与免疫接种：抗蛋白、抗病毒和中和反应的诱导
J Virol. 1985 Aug;55(2):395-401. doi: 10.1128/JVI.55.2.395-401.1985.
4
Antigenic and immunogenic properties of a hepatitis A virus capsid protein expressed in Escherichia coli.在大肠杆菌中表达的甲型肝炎病毒衣壳蛋白的抗原性和免疫原性特性。
J Infect Dis. 1988 Jun;157(6):1203-11. doi: 10.1093/infdis/157.6.1203.
5
Synthesis of immunogenic hepatitis A virus particles by recombinant baculoviruses.重组杆状病毒合成具有免疫原性的甲型肝炎病毒颗粒。
Vaccine. 1993;11(7):706-12. doi: 10.1016/0264-410x(93)90253-t.
6
Primary structure and gene organization of human hepatitis A virus.人类甲型肝炎病毒的一级结构与基因组织
Proc Natl Acad Sci U S A. 1985 May;82(9):2627-31. doi: 10.1073/pnas.82.9.2627.
7
Immunologic priming with recombinant hepatitis A virus capsid proteins produced in Escherichia coli.用在大肠杆菌中产生的重组甲型肝炎病毒衣壳蛋白进行免疫致敏。
J Virol. 1991 May;65(5):2686-90. doi: 10.1128/JVI.65.5.2686-2690.1991.
8
Host antibody response to viral structural and nonstructural proteins after hepatitis A virus infection.
J Infect Dis. 1992 Feb;165(2):273-80. doi: 10.1093/infdis/165.2.273.
9
Characterization of a simian hepatitis A virus (HAV): antigenic and genetic comparison with human HAV.一种猿猴甲型肝炎病毒（HAV）的特性：与人类HAV的抗原性和基因比较。
J Virol. 1989 Nov;63(11):4932-7. doi: 10.1128/JVI.63.11.4932-4937.1989.
10
Mimicry of the immunodominant conformation-dependent antigenic site of hepatitis A virus by motifs selected from synthetic peptide libraries.从合成肽库中筛选的基序对甲型肝炎病毒免疫显性构象依赖性抗原位点的模拟
J Virol. 1995 Sep;69(9):5294-9. doi: 10.1128/JVI.69.9.5294-5299.1995.
引用本文的文献
1
Considerations on Structural Vaccinology and Epitope Screening of Calcium-Dependent Protein Kinases 8 as a Potential Vaccine Target Against .关于将钙依赖性蛋白激酶8作为针对……的潜在疫苗靶点的结构疫苗学及表位筛选的思考
Interdiscip Perspect Infect Dis. 2025 Sep 9;2025:4426082. doi: 10.1155/ipid/4426082. eCollection 2025.
2
Evaluation of a multi-epitope vaccine PME for in mouse model.在小鼠模型中对多表位疫苗PME的评估。
Front Immunol. 2025 Sep 1;16:1652907. doi: 10.3389/fimmu.2025.1652907. eCollection 2025.
3
Sialic Acid-Binding Protein-1 (SABP1) of : Preliminary Computer-Based Epitope Mapping for Enhanced Vaccine Design.唾液酸结合蛋白-1（SABP1）：基于计算机的初步表位图谱分析以优化疫苗设计
J Parasitol Res. 2025 Sep 3;2025:9909421. doi: 10.1155/japr/9909421. eCollection 2025.
4
PdPANA: phagemid display as peptide array for neutralizing antibodies, an engineered vaccine candidate against COVID-19.PdPANA：作为用于中和抗体的肽阵列的噬菌粒展示，一种针对COVID-19的工程疫苗候选物。
Front Syst Biol. 2024 Jun 17;4:1309891. doi: 10.3389/fsysb.2024.1309891. eCollection 2024.
5
Immunoinformatic design of chimeric multiepitope vaccine for the prevention of human metapneumovirus (hMPV).用于预防人偏肺病毒（hMPV）的嵌合多表位疫苗的免疫信息学设计
BMC Infect Dis. 2025 Jul 30;25(1):964. doi: 10.1186/s12879-025-11339-x.
6
Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study.季节性流感疫苗接种后年轻人和老年人中血凝素表位变异及对连续A/维多利亚A(H1N1)毒株的抗体反应：一项初步研究
Vaccines (Basel). 2025 Jul 21;13(7):774. doi: 10.3390/vaccines13070774.
7
Cloning and Expression of a Truncated Form of the p72 Protein of the African Swine Fever Virus (ASFV) for Application in an Efficient Indirect ELISA System.非洲猪瘟病毒（ASFV）p72蛋白截短形式的克隆与表达及其在高效间接酶联免疫吸附测定（ELISA）系统中的应用
Pathogens. 2025 May 29;14(6):542. doi: 10.3390/pathogens14060542.
8
A Structural In Silico Analysis of Novel Epitopes from Proteins for the Serodiagnosis of Toxoplasmosis.用于弓形虫病血清学诊断的蛋白质新表位的结构计算机模拟分析
Int J Mol Sci. 2025 May 14;26(10):4689. doi: 10.3390/ijms26104689.
9
In Silico-Based Investigation of the Immunogenicity and Biochemical Attributes of Apical Membrane Antigen 1 (TgAMA1).基于计算机模拟的顶膜抗原1（TgAMA1）免疫原性和生化特性研究
J Parasitol Res. 2025 Apr 12;2025:3514414. doi: 10.1155/japr/3514414. eCollection 2025.
10
Comparative in vitro immunoreactivity and protein analysis of Trimeresurus albolabris and Tropidolaemus wagleri venoms.白唇竹叶青蛇毒和圆斑蝰蛇毒的体外免疫反应性及蛋白质分析比较
Sci Rep. 2025 Apr 12;15(1):12693. doi: 10.1038/s41598-025-97032-0.
本文引用的文献
1
Molecular cloning and characterization of hepatitis A virus cDNA.甲型肝炎病毒cDNA的分子克隆与特性分析
Proc Natl Acad Sci U S A. 1983 Oct;80(19):5885-9. doi: 10.1073/pnas.80.19.5885.
2
Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides.合成肽引发和诱导抗脊髓灰质炎病毒中和抗体
Nature. 1983;304(5928):699-703. doi: 10.1038/304699a0.
3
Taxonomic classification of hepatitis A virus.甲型肝炎病毒的分类学
Intervirology. 1983;20(1):1-7. doi: 10.1159/000149367.
4
Biophysical and biochemical characterization of hepatitis A virus.甲型肝炎病毒的生物物理和生化特性
Intervirology. 1982;18(3):107-27. doi: 10.1159/000149314.
5
Classification of hepatitis A virus as enterovirus type 72 and of hepatitis B virus as hepadnavirus type 1.甲型肝炎病毒归类为肠道病毒72型，乙型肝炎病毒归类为嗜肝DNA病毒1型。
Intervirology. 1982;18(3):105-6. doi: 10.1159/000149313.
6
Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome.脊髓灰质炎病毒cDNA的分子克隆及病毒基因组完整核苷酸序列的测定。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4887-91. doi: 10.1073/pnas.78.8.4887.
7
Primary structure, gene organization and polypeptide expression of poliovirus RNA.脊髓灰质炎病毒RNA的一级结构、基因组织及多肽表达
Nature. 1981 Jun 18;291(5816):547-53. doi: 10.1038/291547a0.
8
Antibodies specific for the carboxy- and amino-terminal regions of simian virus 40 large tumor antigen.针对猿猴病毒40大T抗原羧基末端和氨基末端区域的特异性抗体。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5197-200. doi: 10.1073/pnas.77.9.5197.
9
Neutralizing monoclonal antibodies to hepatitis A virus: partial localization of a neutralizing antigenic site.甲型肝炎病毒中和单克隆抗体：中和抗原位点的部分定位
J Virol. 1984 Nov;52(2):465-73. doi: 10.1128/JVI.52.2.465-473.1984.
10
Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies.脊髓灰质炎病毒中和表位：用中和性单克隆抗体进行分析和定位
J Virol. 1982 Sep;43(3):997-1005. doi: 10.1128/JVI.43.3.997-1005.1982.
Zotero 插件