Department of Neurology & Stroke, Hertie Institute for Clinical Brain Research, University of Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany; Service of Interdisciplinary Neuromodulation, Laboratory of Neuroscience (LIM27) and National Institute of Biomarkers in Psychiatry (INBioN), Department and Institute of Psychiatry, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, R. Dr. Ovídio Pires de Campos, 785, 01060-970, São Paulo, Brazil.
Department of Neurology & Stroke, Hertie Institute for Clinical Brain Research, University of Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.
Brain Stimul. 2018 Sep-Oct;11(5):1024-1032. doi: 10.1016/j.brs.2018.06.004. Epub 2018 Jun 18.
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with potential for cost-effective therapeutic neuromodulation. Although positive therapeutic effects were found by stimulating the dorsolateral prefrontal cortex (DLPFC), few studies have investigated physiological effects of DLPFC-tDCS.
To investigate effects of tDCS with different parameter settings applied to the left DLPFC on cortical responses, measured by resting-state electroencephalography (rs-EEG) and transcranial magnetic stimulation (TMS)-evoked/induced EEG responses.
22 healthy subjects underwent 5 tDCS sessions with different tDCS parameter settings in a double-blinded randomized crossover design (1: 1.5 mA, anode left-DLPFC, cathode right-DLPFC; 2: 1.5 mA, cathode left-DLPFC, anode right-DLPFC; 3: 0.5 mA, anode left-DLPFC, cathode right-DLPFC; 4: 1.5 mA, anode left-DLPFC, cathode left deltoid muscle; 5: sham stimulation). Rs-EEG and TMS-EEG were recorded before and after tDCS.
Rs-EEG power spectrum analysis showed no difference comparing baseline with post stimulation in any of the tDCS conditions. TMS-EEG evoked potential amplitude decreased in parietal cortex after 1.5 mA left-DLPFC anodal tDCS, and TMS-induced gamma and theta oscillations decreased after all conditions using left-DLPFC anodal tDCS. Left-DLPFC cathodal tDCS did not lead to significant change. None of the post-intervention changes was different when comparing the effects across conditions, including sham.
Our study does not provide evidence that a single tDCS session results in significant changes in rs-EEG, using the current stimulation parameters. Significant changes in EEG responses to TMS pulses were observed following the anodal 1.5 mA tDCS interventions, although these changes were not statistically significant in a group comparison.
经颅直流电刺激（tDCS）是一种具有成本效益的神经调节治疗潜力的非侵入性脑刺激技术。虽然刺激背外侧前额叶皮层（DLPFC）可产生积极的治疗效果，但很少有研究调查 DLPFC-tDCS 的生理效应。
通过静息态脑电图（rs-EEG）和经颅磁刺激（TMS）诱发/诱导 EEG 反应，研究不同参数设置的 tDCS 对左 DLPFC 皮质反应的影响。
22 名健康受试者以双盲随机交叉设计（1：1.5mA，阳极左 DLPFC，阴极右 DLPFC；2：1.5mA，阴极左 DLPFC，阳极右 DLPFC；3：0.5mA，阳极左 DLPFC，阴极右 DLPFC；4：1.5mA，阳极左 DLPFC，阴极左三角肌；5：假刺激）进行 5 次 tDCS 治疗。在 tDCS 前后记录 rs-EEG 和 TMS-EEG。
rs-EEG 功率谱分析显示，在任何 tDCS 条件下，与刺激后相比，基线均无差异。1.5mA 左 DLPFC 阳极 tDCS 后顶叶皮质 TMS 诱发电位振幅降低，所有左 DLPFC 阳极 tDCS 后 TMS 诱导的伽马和 theta 振荡均降低。左 DLPFC 阴极 tDCS 并未导致显著变化。在比较各条件下的干预后变化时，包括假刺激，均未发现任何差异。
我们的研究没有提供证据表明单次 tDCS 治疗会导致当前刺激参数下 rs-EEG 发生显著变化。在 1.5mA 阳极 tDCS 干预后，TMS 脉冲的 EEG 反应发生了显著变化，尽管在组间比较中这些变化没有统计学意义。
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