McLaughlin Thomas, Blum Kenneth, Steinberg Bruce, Siwicki David, Campione Joseph, Badgaiyan Rajendra D, Braverman Eric R, Modestino Edward J, Gondré-Lewis Marjorie C, Baron David, Mash Deborah C, Giordano John, Thanos Panayotis K
Center for Psychiatric Medicine, North Andover, MA, USA.
Department of Psychiatry, University of Florida & McKnight Brain Institute, College of Florida, Gainesville, FL, USA.
J Reward Defic Syndr Addict Sci. 2017;3(2):28-31. doi: 10.17756/jrdsas.2017-038. Epub 2017 Dec 30.
The slaughters in Las Vegas and Sutherland Springs demand explanation, in the face of the ineffable. An understanding of the shooters' motives could restore our trust in our mutually cooperative existence. In this short communication we provide post-hoc rationale of both Stephen Paddock (Las Vegas mass shooting) and Devin Kelley (Southerland Springs mass shooting) and hypothesize that these shooters had genetically induced "Reward Deficiency Syndrome" (RDS) and a hypodopaminergia trait/state. In this particular case we are in pursuit of trying to obtain postmortem samples of mass shooters for subsequent epigenetic and neurogenetic analyses. It is our contention that early genetic identification of RDS and its pathological behaviors including hyper - sexuality, violence, a love for guns, even in children, could be a giant step forward in potentially saving lives.
面对拉斯维加斯和萨瑟兰斯普林斯发生的屠杀事件,面对这难以言喻的一切,需要给出解释。了解枪手的动机或许能恢复我们对彼此合作共存的信任。在这篇简短的通讯中,我们提供了斯蒂芬·帕多克(拉斯维加斯大规模枪击案)和德文·凯利(萨瑟兰斯普林斯大规模枪击案)的事后推理,并假设这些枪手患有基因诱导的“奖励缺乏综合征”(RDS)以及低多巴胺能特质/状态。在这个特定案例中,我们正努力获取大规模枪击案枪手的尸检样本,用于后续的表观遗传学和神经遗传学分析。我们认为,对RDS及其包括性欲亢进、暴力、对枪支的喜爱等病理行为进行早期基因识别,哪怕是针对儿童,都可能是在拯救生命方面向前迈出的巨大一步。