国家癌症中心一系列连续结直肠癌病例中错配修复缺陷系统的频率
Frequency of Defective Mismatch Repair System in a Series of Consecutive Cases of Colorectal Cancer in a National Cancer Center.
作者信息
López-Correa Patricia E, Lino-Silva Leonardo S, Gamboa-Domínguez Armando, Zepeda-Najar César, Salcedo-Hernández Rosa A
机构信息
Surgical pathology, Instituto Nacional de Cancerología, Mexico City, Mexico.
Surgical pathology, Fundación Universitaria de Ciencias de la Salud (FUCS), Hospital de San José, Bogotá, Colombia.
出版信息
J Gastrointest Cancer. 2018 Sep;49(3):379-384. doi: 10.1007/s12029-018-0132-1.
BACKGROUND
The frequency of colorectal cancer (CRC) with defective mismatch repair (dMMR) is estimated between 5 and 15%. In our population, the frequency of dMMR is unknown. Our objective was to show the frequency of dMMR.
METHODS
Determination of dMMR with immunohistochemistry was performed prospectively for 202 patients who presented consecutively with CRC for the first time at our institution.
RESULTS
The median age was 59 years (IQR 47 to 68), 119 (58.9%) were women, and 43 (21.3%) cases showed dMMR. The only clinicopathological characteristics associated with dMMR were the location in the right colon and the presence of a family history of cancer. In the multivariate analysis, only the presence of the tumor in the right colon was associated with dMMR (OR = 5.823, 95%-C.I. = 2.653-12.784, p < .001).
CONCLUSION
The 21.3% of the cases demonstrated a dMMR and the only clinical-pathological characteristic associated with dMMR was location in the right colon.
背景
错配修复缺陷（dMMR）的结直肠癌（CRC）发生率估计在5%至15%之间。在我们的人群中，dMMR的发生率尚不清楚。我们的目的是展示dMMR的发生率。
方法
对在我们机构首次连续就诊的202例CRC患者前瞻性地进行免疫组织化学法检测dMMR。
结果
中位年龄为59岁（四分位间距47至68岁），119例（58.9%）为女性，43例（21.3%）病例显示dMMR。与dMMR相关的唯一临床病理特征是肿瘤位于右半结肠以及存在癌症家族史。在多变量分析中，仅肿瘤位于右半结肠与dMMR相关（比值比=5.823，95%置信区间=2.653至12.784，p<0.001）。
结论
21.3%的病例显示dMMR，与dMMR相关的唯一临床病理特征是位于右半结肠。
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