从表现蛋下降综合征的成年鸭中分离到的新型鸭甲型肝炎病毒 1 型。
Novel duck hepatitis A virus type 1 isolates from adult ducks showing egg drop syndrome.
机构信息
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, Taian 201718, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Taian 201718, China; Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Taian 271018, China.
Ecolovo Group, Nanjing 210041, China.
出版信息
Vet Microbiol. 2018 Jul;221:33-37. doi: 10.1016/j.vetmic.2018.05.023. Epub 2018 May 30.
Generally, duck hepatitis A virus type 1 (DHAV-1) only infects young ducklings. Since December 2016, severe outbreaks of duck viral infection with egg drop, feed consumption decline, and ovary-oviduct disease have occurred in some laying duck flocks in Shandong Province of China. DHAV-1 isolated from the affected ducks was confirmed as the causative pathogen of the egg drop. Compared with other DHAV-1 strains, the novel isolate has three special amino acid mutation points in the most variable regions at the C-terminus of VP1. The experimental infection in laying ducks indicated that successful immunization with DHAV-1 vaccine could protect laying duck from infection. To the best of our knowledge, this is the first reported incidence of a severe duck disease outbreak involving egg drop syndrome caused by DHAV-1.
一般来说，鸭甲型肝炎病毒 1 型（DHAV-1）仅感染雏鸭。自 2016 年 12 月以来，中国山东省的一些产蛋鸭群中发生了严重的鸭病毒性感染，出现产蛋下降、采食量下降和卵巢-输卵管疾病。从受感染鸭中分离到的 DHAV-1 被确认为产蛋下降的致病病原体。与其他 DHAV-1 株相比，新型分离株在 VP1 末端最可变区有三个特殊的氨基酸突变点。在产蛋鸭中的实验感染表明，DHAV-1 疫苗的成功免疫可以保护产蛋鸭免受感染。据我们所知，这是首次报道由 DHAV-1 引起的严重鸭病暴发，涉及产蛋下降综合征。
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