Targeting platelet EPCR for better therapeutic factor VIIa activity.
作者信息
Gu S X, Lentz S R
机构信息
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
出版信息
J Thromb Haemost. 2018 Sep;16(9):1814-1816. doi: 10.1111/jth.14231. Epub 2018 Aug 3.
Abstract
摘要
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本文引用的文献
1
Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity.
J Thromb Haemost. 2018 Sep;16(9):1817-1829. doi: 10.1111/jth.14165. Epub 2018 Jun 27.
2
Endothelial cell protein C receptor-dependent signaling.
Curr Opin Hematol. 2018 May;25(3):219-226. doi: 10.1097/MOH.0000000000000416.
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Recent advances in developing specific therapies for haemophilia.
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TRUST trial: BAY 86-6150 use in haemophilia with inhibitors and assessment for immunogenicity.
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Pharmacological concentrations of recombinant factor VIIa restore hemostasis independent of tissue factor in antibody-induced hemophilia mice.
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Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity.
J Thromb Haemost. 2015 Nov;13(11):1989-98. doi: 10.1111/jth.13141. Epub 2015 Oct 13.
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Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment.
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Endothelial cell protein C receptor: a multiliganded and multifunctional receptor.
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