Department of Applied Biology, Institute for Applied Biosciences, Karlsruhe Institute of Technology (CS), Karlsruhe, Germany.
Instituto de Tecnologia Química e Biológica António Xavier, Universidade NOVA de Lisboa, Av. da República-EAN, Oeiras, 2780-157, Portugal.
Mol Microbiol. 2018 Sep;109(5):571-583. doi: 10.1111/mmi.14067. Epub 2018 Jul 31.
Shewanella oneidensis is the best understood model organism for the study of dissimilatory iron reduction. This review focuses on the current state of our knowledge regarding this extracellular respiratory process and highlights its physiologic, regulatory and biochemical requirements. It seems that we have widely understood how respiratory electrons can reach the cell surface and what the minimal set of electron transport proteins to the cell surface is. Nevertheless, even after decades of work in different research groups around the globe there are still several important questions that were not answered yet. In particular, the physiology of this organism, the possible evolutionary benefit of some responses to anoxic conditions, as well as the exact mechanism of electron transfer onto solid electron acceptors are yet to be addressed. The elucidation of these questions will be a great challenge for future work and important for the application of extracellular respiration in biotechnological processes.
希瓦氏菌属（Shewanella oneidensis）是研究异化铁还原的最佳模式生物。本综述重点介绍了目前对这种细胞外呼吸过程的认识，并强调了其生理、调节和生化要求。似乎我们已经广泛了解了呼吸电子如何到达细胞表面，以及到达细胞表面的电子传递蛋白的最小集合是什么。然而，即使在全球不同研究小组进行了几十年的工作之后，仍然有几个重要的问题尚未得到解答。特别是该生物体的生理学、对缺氧条件的某些反应的可能进化优势，以及电子转移到固体电子受体的确切机制，都有待解决。这些问题的阐明将是未来工作的巨大挑战，对于细胞外呼吸在生物技术过程中的应用也非常重要。
