甾体磷酸酯和膦酸酯及其生物活性。

Steroid phosphate esters and phosphonosteroids and their biological activities.

机构信息

Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge, AB, T1K 1L6, Canada.

Biochemical Lab, National Scientific Center of Marine Biology, 17 Palchevsky Str., Vladivostok, Russia, 690041.

出版信息

Appl Microbiol Biotechnol. 2018 Sep;102(18):7679-7692. doi: 10.1007/s00253-018-9206-z. Epub 2018 Jul 11.

DOI:10.1007/s00253-018-9206-z

PMID:29998410

Abstract

Steroid phosphate esters are very rare natural lipids that have been comparatively recently isolated from fractions of polar lipids of marine sponges and starfish. These steroids exhibit interesting biological activities. When using the PASS computer program, we showed that many of steroid phosphate esters showed antifungal, antihypercholesterolemic, anesthetic, and other activities with a confidence of 73 to 93%. In addition, some of them can be used as inhibitors of cholesterol synthesis and show hepatoprotection properties. Phosphonosteroids demonstrate antineoplastic and antihypercholesterolemic activities with a certainty of 85 to 90%. And also, they can be used as ovulation inhibitors or female steroid contraceptives with confidence from 86 to 98%.

摘要

甾体磷酸酯是非常罕见的天然脂质，最近才从海洋海绵和海星极性脂质的馏分中分离出来。这些甾体具有有趣的生物活性。在使用 PASS 计算机程序时，我们发现许多甾体磷酸酯具有抗真菌、降胆固醇、麻醉等活性，置信度为 73%至 93%。此外，它们中的一些可以用作胆固醇合成抑制剂，并具有保肝作用。膦甾醇具有抗肿瘤和降胆固醇活性，确定性为 85%至 90%。并且，它们可以作为排卵抑制剂或女性甾体避孕药使用，置信度为 86%至 98%。