北京眼研究中眼底网格状图案的长期进展及其影响因素。
Long-term Progression and Risk Factors of Fundus Tessellation in the Beijing Eye Study.
机构信息
Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China.
出版信息
Sci Rep. 2018 Jul 13;8(1):10625. doi: 10.1038/s41598-018-29009-1.
To assess the progression of fundus tessellation, color fundus photographs of the participants of the longitudinal population-based Beijing Eye Study were examined. The study included 4439 subjects in 2001 and 2695 (66.4% of the surviving) individuals in 2011. Larger progression in macular fundus tessellation (mean: 0.24 ± 0.48 grades) was associated (multivariate analysis; correlation coefficient r: 0.53) with thinner subfoveal choroidal thickness in 2011 (P < 0.001; standardized regression coefficient beta: -0.37), older age (P < 0.001; beta: 0.22), higher level of education (P < 0.001; beta: 0.09), more myopic change in refractive error (P < 0.001; beta: -0.09) and lower cognitive function score (P = 0.02; beta: -0.05). Larger increase in peripapillary fundus tessellation (mean: 0.19 ± 0.26 grades) correlated with thinner peripapillary choroidal thickness in 2011 (P < 0.001; beta: -0.35), older age (P < 0.001; beta: 0.20), worse best corrected visual acuity (P = 0.001; beta: 0.07), more myopic change in refractive error (P < 0.001; beta: -0.07) and higher prevalence of ever smoking (P = 0.004; beta: 0.05). The increase in macular fundus tessellation, as a surrogate for thinning of the posterior choroid, was associated with lower cognitive function, after adjusting for choroidal thickness, age, educational level and change in refractive error. The findings point to the clinical value of the assessment of fundus tessellation and suggest potential associations between cognitive function and fundus tessellation/choroidal thickness.
为了评估眼底镶嵌图案的进展，我们检查了参加基于人群的北京眼研究的参与者的眼底彩色照片。该研究包括 2001 年的 4439 名受试者和 2011 年的 2695 名（存活者的 66.4%）个体。在 2011 年，黄斑部眼底镶嵌图案的较大进展（平均：0.24±0.48 级）与较薄的中心凹下脉络膜厚度相关（多元分析；相关系数 r：0.53）（P<0.001；标准化回归系数β：-0.37），年龄较大（P<0.001；β：0.22），教育程度较高（P<0.001；β：0.09），近视变化较大（P<0.001；β：-0.09）和认知功能评分较低（P=0.02；β：-0.05）。视盘周围眼底镶嵌图案的较大增加（平均：0.19±0.26 级）与 2011 年较薄的视盘周围脉络膜厚度相关（P<0.001；β：-0.35），年龄较大（P<0.001；β：0.20），最佳矫正视力较差（P=0.001；β：0.07），近视变化较大（P<0.001；β：-0.07）和吸烟史更常见（P=0.004；β：0.05）。调整脉络膜厚度、年龄、教育程度和屈光不正变化后，黄斑部眼底镶嵌图案的增加作为后脉络膜变薄的替代指标，与认知功能较低相关。这些发现表明了评估眼底镶嵌图案的临床价值，并提示认知功能与眼底镶嵌图案/脉络膜厚度之间存在潜在关联。
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