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正常及EB病毒转化淋巴细胞中β-肾上腺素能刺激的腺苷酸环化酶活性

Beta-adrenergic-stimulated adenylate cyclase activity in normal and EBV-transformed lymphocytes.

作者信息

Ebstein R P, Steinitz M, Mintzer J, Lipshitz I, Stessman J

出版信息

Experientia. 1985 Dec 15;41(12):1552-4. doi: 10.1007/BF01964803.

DOI:10.1007/BF01964803
PMID:3000812
Abstract

Beta-adrenergic-associated cyclic AMP accumulation was studied in intact lymphocytes before and after transformation with Epstein-Barr virus into immortal cell lines. Although a marked reduction in isoproterenol-stimulated cyclic AMP synthesis was observed in transformed cells, forskolin-stimulated cyclic AMP accumulation was preserved. A parallel loss of 125-iodocyanopindolol binding sites suggests that the reduction in beta-adrenergic-stimulated AMP synthesis is due to receptor down-regulation.

摘要

在完整的淋巴细胞被爱泼斯坦 - 巴尔病毒转化为永生细胞系之前和之后，研究了β - 肾上腺素能相关的环磷酸腺苷（cAMP）积累情况。尽管在转化细胞中观察到异丙肾上腺素刺激的cAMP合成显著减少，但福斯高林刺激的cAMP积累得以保留。125 - 碘氰吲哚洛尔结合位点的平行丧失表明，β - 肾上腺素能刺激的AMP合成减少是由于受体下调所致。

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本文引用的文献

1
SEPARATION OF WHITE BLOOD CELLS.白细胞的分离
Nature. 1964 Nov 21;204:793-4. doi: 10.1038/204793a0.
2
Immortalization of human lymphocytes by Epstein-Barr virus.爱泼斯坦-巴尔病毒使人类淋巴细胞永生化。
Yale J Biol Med. 1982 May-Aug;55(3-4):305-10.
3
Deficient activity of receptor-cyclase coupling protein is transformed lymphoblasts of patients with pseudohypoparathyroidism, type I.I型假性甲状旁腺功能减退症患者转化淋巴细胞中受体 - 环化酶偶联蛋白活性不足。
J Clin Endocrinol Metab. 1982 Jul;55(1):113-7. doi: 10.1210/jcem-55-1-113.
4
The beta-adrenergic receptor in human lymphocytes: subclassification by the use of a new radio-ligand, (+/-)-125 Iodocyanopindolol.人淋巴细胞中的β-肾上腺素能受体：使用新型放射性配体（±）-125碘氰吲哚洛尔进行亚分类
Life Sci. 1981 Nov 23;29(21):2189-98. doi: 10.1016/0024-3205(81)90490-2.
5
Continuous production of monoclonal rheumatoid factor by EBV-transformed lymphocytes.EB病毒转化的淋巴细胞持续产生单克隆类风湿因子。
Nature. 1980 Oct 2;287(5781):443-5. doi: 10.1038/287443a0.
6
Alzheimer's disease: isoproterenol and prostaglandin E1-stimulated cyclic AMP accumulation in lymphocytes.阿尔茨海默病：异丙肾上腺素和前列腺素E1刺激淋巴细胞中环磷酸腺苷的积累。
Life Sci. 1984 Jun 4;34(23):2239-43. doi: 10.1016/0024-3205(84)90211-x.
7
Beta-adrenergic receptors: biochemical mechanisms of physiological regulation.β-肾上腺素能受体：生理调节的生化机制
Physiol Rev. 1984 Apr;64(2):661-743. doi: 10.1152/physrev.1984.64.2.661.
8
Phorbol myristate acetate stimulation of lymphocyte guanylate cyclase and cyclic guanosine 3':5'-monophosphate phosphodiesterase and reduction of adenylate cyclase.佛波醇肉豆蔻酸酯乙酸盐对淋巴细胞鸟苷酸环化酶和环磷酸鸟苷3':5'-单磷酸磷酸二酯酶的刺激作用以及对腺苷酸环化酶的抑制作用。
Cancer Res. 1983 Jan;43(1):150-8.
9
Acute regulation of beta adrenergic catecholamine sensitivity in human lymphocytes.人淋巴细胞中β-肾上腺素能儿茶酚胺敏感性的急性调节
J Pharmacol Exp Ther. 1980 Sep;214(3):554-60.
10
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Life Sci. 1984 Oct 22;35(17):1795-802. doi: 10.1016/0024-3205(84)90277-7.