平面细胞极性在器官形成中的作用。

Planar cell polarity in organ formation.

机构信息

Cardiovascular Research Centre, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.

Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK.

出版信息

Curr Opin Cell Biol. 2018 Dec;55:96-103. doi: 10.1016/j.ceb.2018.06.011. Epub 2018 Jul 14.

DOI:10.1016/j.ceb.2018.06.011

PMID:30015152

Abstract

The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent extension and collective cell migration. In this review we discuss the increasingly prominent role of the PCP pathway in organogenesis, focusing on the lungs, kidneys and heart. We also highlight emerging evidence that PCP gene mutations are associated with adult diseases.

摘要

平面细胞极性（PCP）通路控制着许多物种的多种形态事件。在胚胎发育过程中，PCP 通路调节细胞群的协调行为，以指导形态发生过程，如会聚延伸和集体细胞迁移。在这篇综述中，我们讨论了 PCP 通路在器官发生中的作用越来越突出，重点是肺、肾和心脏。我们还强调了新兴的证据表明 PCP 基因突变与成人疾病有关。