评估新诊断和长期 2 型糖尿病成人的左旋肉碱和总抗氧化能力水平。

Assessing the Levels of L-Carnitine and Total Antioxidant Capacity in Adults With Newly Diagnosed and Long-Standing Type 2 Diabetes.

机构信息

Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran; Student Research Committee, Babol University of Medical Sciences, Babol, Iran.

Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

出版信息

Can J Diabetes. 2019 Feb;43(1):46-50.e1. doi: 10.1016/j.jcjd.2018.03.009. Epub 2018 Mar 29.

DOI:10.1016/j.jcjd.2018.03.009

PMID:30026047

Abstract

OBJECTIVES

This study is essentially a correlative study that examines the potential of reduced levels of L-carnitine (LC) when combined with the pathophysiology of type 2 diabetes. The aim of the study was to assess the levels of LC, total antioxidant capacity (TAOC), fasting blood sugar (FBS), triglycerides and cholesterol in people with newly diagnosed and long-standing type 2 diabetes and in healthy controls.

METHODS

The study was done in 90 adult subjects, including 30 with newly diagnosed diabetes, 30 with long-standing type 2 diabetes and 30 healthy controls. Plasma samples were used to assay the biochemical parameters.

RESULTS

In this study, both groups (newly diagnosed and long-standing type 2 diabetes) were significantly different in baseline characteristics, such as age, height, weight, body mass index, FBS, cholesterol and triglycerides, compared to the healthy controls. Plasma LC levels in patients with newly diagnosed and long-standing type 2 diabetes were significantly lower than in healthy controls (p<0.001). Also, the mean plasma TAOC level in the patients with newly diagnosed and long-standing type 2 diabetes was slightly lower than in the healthy controls. Nevertheless, TAOC levels were not significantly different across all the groups (p=0.87). The plasma LC levels were significantly positive when compared to the plasma TAOC levels (r=0.516), which means that an increase in LC levels is associated with an increase in TAOC levels. However, a negative correlation was observed between LC levels and FBS (r=-0.387), triglycerides (-0.159) and body mass indexes (r=-0.068). This means that a decrease in LC levels is associated with increases in FBS, triglyceride and body mass index levels.

CONCLUSIONS

According to the effects of reduced LC levels on the metabolic profiles of patients with long-standing type 2 diabetes, setting the LC content value to prevent diabetes through the use of effective drugs or nutrition containing LC can be useful in managing diabetes.

摘要

目的

本研究本质上是一项相关性研究，旨在探讨左旋肉碱（LC）水平降低与 2 型糖尿病病理生理学之间的潜在关系。本研究旨在评估初诊和长期 2 型糖尿病患者以及健康对照者的 LC 水平、总抗氧化能力（TAOC）、空腹血糖（FBS）、甘油三酯和胆固醇水平。

方法

该研究纳入了 90 名成年受试者，包括 30 名初诊糖尿病患者、30 名长期 2 型糖尿病患者和 30 名健康对照者。使用血浆样本测定生化参数。

结果

本研究中，与健康对照组相比，新诊断和长期 2 型糖尿病组在年龄、身高、体重、体重指数、FBS、胆固醇和甘油三酯等基线特征方面存在显著差异。新诊断和长期 2 型糖尿病患者的血浆 LC 水平明显低于健康对照组（p<0.001）。此外，新诊断和长期 2 型糖尿病患者的平均血浆 TAOC 水平略低于健康对照组。然而，各组间 TAOC 水平无显著差异（p=0.87）。与 TAOC 水平相比，血浆 LC 水平呈显著正相关（r=0.516），这意味着 LC 水平的升高与 TAOC 水平的升高相关。然而，LC 水平与 FBS（r=-0.387）、甘油三酯（-0.159）和体重指数（r=-0.068）呈负相关。这意味着 LC 水平的降低与 FBS、甘油三酯和体重指数水平的升高相关。