5-碘-1,2,3-三唑引发的串联环化反应构建 2-(1-氨烷基)苯并恶唑。
Annulation-Induced Cascade Transformation of 5-Iodo-1,2,3-triazoles to 2-(1-Aminoalkyl)benzoxazoles.
机构信息
Chemistry Department , M. V. Lomonosov Moscow State University , 1/3 Leninskiye Gory , Moscow 119991 , Russia.
出版信息
Org Lett. 2018 Aug 3;20(15):4467-4470. doi: 10.1021/acs.orglett.8b01755. Epub 2018 Jul 24.
PMID:30040429
Abstract
Base-mediated cyclization of (5-iodo-1,2,3-triazolyl)phenols was proposed as a new synthetic strategy for the in situ generation of diazoimines via electrocyclic ring opening of the fused heterocycle. Cu-catalyzed amination of the intermediate diazoalkanes was employed to develop an efficient cascade approach to functionalized benzoxazoles.
摘要
提出了一种新的合成策略，即通过稠合杂环的电环开环，将（5-碘-1,2,3-三唑基）苯酚进行基底介导的环化反应，从而原位生成重氮亚胺。通过铜催化的中间重氮烷烃的氨基化反应，开发了一种有效的级联方法，用于构建功能化的苯并恶唑。
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