快速眼动睡眠行为障碍和帕金森病的自主汗液反应。

Autonomic Sweat Responses in REM Sleep Behavior Disorder and Parkinsonism.

机构信息

Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.

College of Medicine, Sultan Qaboos University, Muscat, Oman.

出版信息

J Parkinsons Dis. 2018;8(3):463-468. doi: 10.3233/JPD-181357.

DOI:10.3233/JPD-181357

PMID:30040743

Abstract

BACKGROUND

Autonomic dysfunctions including sudomotor abnormalities commonly occur in early Parkinson's disease (PD), but little is known about potential sudomotor abnormalities in idiopathic REM Sleep Behavior Disorder (iRBD), a strong prodromal marker of PD.

OBJECTIVE

Our aim was to assess sudomotor dysfunction by galvanic skin response using SudoScan, as well as other autonomic markers in 49 iRBD, 40 PD (21 with RBD, 19 without), 20 atypical parkinsonisms, and 41 age-matched controls.

METHODS

All subjects underwent SudoScan of their hands and feet, a 30-second electrocardiogram with assessment of beat-to-beat variability, assessment of orthostatic blood pressure changes and autonomic symptom questionnaires.

RESULTS

The galvanic skin response in the hands of PD patients with RBD was significantly smaller than controls (hand mean difference = -7.877, 95% CI (-13.283, -2.470), p-value = 0.004) and PD patients without RBD (hand mean difference = -9.578, 95% CI (-17.215, -1.941), p-value = 0.014). iRBD and atypical parkinsonism did not have different SudoScan profiles than controls.

CONCLUSIONS

Galvanic skin responses, as measured by SudoScan did not demonstrate significant sudomotor dysfunction in iRBD, but decreases were seen in the PD subtype associated with RBD.

摘要

背景

自主神经功能障碍包括出汗异常，在早期帕金森病（PD）中很常见，但对于特发性 REM 睡眠行为障碍（iRBD），即 PD 的一个强烈前驱标志物，潜在的出汗功能障碍知之甚少。

目的

我们的目的是使用 SudoScan 通过皮肤电反应评估 49 例 iRBD、40 例 PD（21 例伴 RBD，19 例不伴 RBD）、20 例非典型帕金森病和 41 名年龄匹配对照者的自主神经功能障碍。

方法

所有受试者均接受手部和足部 SudoScan 检查、30 秒心电图检查，评估心率变异性，评估直立位血压变化和自主神经症状问卷。

结果

伴 RBD 的 PD 患者的皮肤电反应明显小于对照组（手部平均差异=-7.877，95%CI（-13.283，-2.470），p 值=0.004）和不伴 RBD 的 PD 患者（手部平均差异=-9.578，95%CI（-17.215，-1.941），p 值=0.014）。iRBD 和非典型帕金森病与对照组的 SudoScan 谱没有不同。