Romagnoli Stefano, Baldan Anna, Ferro Silvia, Righetti Camilla, Scenna Ludovico, Gabai Gianfranco, Badon Tamara, Fontaine Christelle, Mollo Antonio, Stelletta Calogero, Milani Chiara
1 Department of Animal Medicine, Production and Health, University of Padova, Padova, Italy.
2 Private Practitioner.
J Feline Med Surg. 2019 Jun;21(6):507-519. doi: 10.1177/1098612X18788157. Epub 2018 Jul 30.
The objective of this study was to assess duration of efficacy, side effects and return to fertility following use of the 9.4 mg deslorelin implant (Suprelorin 12; Virbac) in cats, and test whether efficacy and duration of action are influenced by implantation site (interscapular vs periumbilical).
Sixteen healthy adult tom cats were checked with (1) reproductive examination, (2) gonadotropin-releasing hormone stimulation test and (3) semen collection until achievement of sterility, then with (1) and (2) only at 2, 4, 6 and 12 months, and every 6 months thereafter until treatment effect disappeared.
Serum testosterone reached basal levels by 7 days post-treatment. Semen quality improved initially then started to worsen by 1 month post-treatment and after 70 days post-treatment all cats were sterile. Early in the third month post-treatment there was a significant decrease in testicular volume and penile spikes. Testicular histology was normal upon neutering performed after resumption of fertility. No injection site lesions or treatment-related side effects were observed. There was no difference between periumbilical and interscapular placement for all criteria, but there was a trend for the decrease in testicular volume to last longer and for the regression of penile spikes to start sooner after interscapular administration. One of 16 cats did not respond to treatment. Six cats were lost at variable times during the study while fully responding to treatment. In the cats that completed the study, normal fertility was regained after 805 days, on average, but with a variable duration of effect from 750-850 days.
Treatment with a 9.4 mg deslorelin implant in male cats was effective for a period of 750-850 days, which is 1.5-2 times longer than the effect of the 4.7 mg deslorelin implant. Fertility (based on serum testosterone production and the presence of penile spikes) was regained at the end of the study. Placing implants in the intrascapular vs periumbilical location did not affect duration of suppression of testosterone production. The interscapular location may be characterised by a better efficacy, although further studies are needed to clarify this issue.
本研究的目的是评估9.4毫克醋酸去甲雄三烯醇酮植入剂（Suprelorin 12；维克）用于猫时的疗效持续时间、副作用以及生育恢复情况，并测试疗效和作用持续时间是否受植入部位（肩胛间与脐周）的影响。
对16只健康成年雄猫进行检查，首先通过（1）生殖系统检查、（2）促性腺激素释放激素刺激试验和（3）精液采集直至达到不育状态，之后仅在2、4、6和12个月时进行（1）和（2）项检查，此后每6个月检查一次，直至治疗效果消失。
治疗后7天血清睾酮水平降至基础水平。精液质量最初有所改善，但治疗后1个月开始恶化，治疗后70天所有猫均不育。治疗后第三个月初，睾丸体积和阴茎棘显著减小。恢复生育后进行去势时，睾丸组织学正常。未观察到注射部位病变或与治疗相关的副作用。所有标准下，脐周与肩胛间植入部位之间均无差异，但肩胛间给药后，睾丸体积减小持续时间更长，阴茎棘消退开始得更早，存在这样一种趋势。16只猫中有1只对治疗无反应。6只猫在研究期间不同时间点失访，当时它们对治疗完全有反应。在完成研究的猫中，平均805天后恢复正常生育能力，但效果持续时间从750 - 850天不等。
9.4毫克醋酸去甲雄三烯醇酮植入剂对雄猫的治疗效果持续750 - 850天，比4.7毫克醋酸去甲雄三烯醇酮植入剂的效果长1.5 - 2倍。研究结束时恢复了生育能力（基于血清睾酮产生和阴茎棘的存在）。将植入剂置于肩胛间与脐周位置对睾酮产生的抑制持续时间无影响。肩胛间位置可能疗效更佳，不过需要进一步研究来阐明这一问题。
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