Kamal Shagufta, Akhter Naheed, Khan Samreen Gul, Kiran Shumaila, Farooq Tahir, Akram Muhammad, Shah Syed Muhammad Ali, Tahir Imtiaz Mahmood, Akhlaq Muhammad, Said Fahad, Zaheer Jawad
Department of Biochemistry, Government College University, Faisalabad, Pakistan.
College of Allied Health Professionals, Directorate of Medical Sciences, Government College University, Faisalabad, Pakistan.
Pak J Pharm Sci. 2018 Jul;31(4(Supplementary)):1539-1548.
Diabetes is a condition where the fasting blood glucose level elevated above the normal range (80-120mg/dL). This increase in blood glucose level may be due to the insulin deficiency i.e. insulin dependent diabetes mellitus (IDDM or type I) or due to insulin resistance i.e. non-insulin dependent diabetes mellitus (NIDDM or type II). Diabetes leads to severe complications in the body even life treating complications e.g. nephropathy, retinopathy, neuropathy increased vascular permeability and delayed wound healing if left untreated. Different drugs are used for the treatment of diabetes mellitus, but synthetic drugs are costly and possess severe side effects. So, more emphasis is being placed on the use of traditional medicines because these sources have fewer side effects than the synthetics drugs and are economical. So the white skinned sweet potato (Ipomoea batatas L.) peel-off was selected for its anti-diabetic effect as well as to see its effects on biochemical parameters. Both young (3-4 months) and old (up to 1 year) Wistar rats were selected for current study. It was found that the aqueous extract of WSSP peel-off had shown beneficial effects. In addition to the decrease in blood glucose level it also decreased protein glycation level total cholesterol, triglycerides, and LDL-cholesterol. Increase in HDL-cholesterol was also observed after treating the rats with aqueous extract of Ipomoea batatas. Additionally, WSSP peel-off had also shown positive results on total protein concentration, albumin, globulin, and plasma enzymes (SGOT and SGPT). Further research would be needed in order to purify the anti-diabetic components and it should be available in compact dose form for all diabetic patients.
糖尿病是一种空腹血糖水平高于正常范围（80 - 120毫克/分升）的病症。血糖水平的升高可能是由于胰岛素缺乏，即胰岛素依赖型糖尿病（IDDM或I型），或者是由于胰岛素抵抗，即非胰岛素依赖型糖尿病（NIDDM或II型）。糖尿病会导致身体出现严重并发症，甚至危及生命的并发症，如肾病、视网膜病变、神经病变、血管通透性增加以及伤口愈合延迟，如果不进行治疗的话。不同的药物用于治疗糖尿病，但合成药物成本高且具有严重的副作用。因此，人们更加重视使用传统药物，因为这些药物的副作用比合成药物少，而且经济实惠。所以，白皮红薯（Ipomoea batatas L.）的外皮因其抗糖尿病作用以及对生化参数的影响而被选中。本研究选用了年轻（3 - 4个月）和年老（长达1年）的Wistar大鼠。研究发现，白皮红薯外皮的水提取物显示出有益效果。除了降低血糖水平外，它还降低了蛋白质糖基化水平、总胆固醇、甘油三酯和低密度脂蛋白胆固醇。在用红薯水提取物处理大鼠后，还观察到高密度脂蛋白胆固醇有所增加。此外，白皮红薯外皮对总蛋白浓度、白蛋白、球蛋白和血浆酶（谷草转氨酶和谷丙转氨酶）也显示出积极结果。为了纯化抗糖尿病成分，还需要进一步研究，并且应该以紧凑剂型提供给所有糖尿病患者。
