Centro de Investigaciones Costeras- Universidad de Atacama (CIC-UDA), Avenida Copayapu 485, Copiapó, Región Atacama, Chile.
Centro de Investigaciones Costeras- Universidad de Atacama (CIC-UDA), Avenida Copayapu 485, Copiapó, Región Atacama, Chile.
Environ Pollut. 2018 Nov;242(Pt B):1659-1668. doi: 10.1016/j.envpol.2018.07.111. Epub 2018 Jul 24.
The environmental quality of an acid mine drainage polluted river (Odiel River) in the Iberian Pyrite Belt (SW Spain) was assessed by combining analyses of biomarkers (DNA strand breaks, LPO, EROD, GST, GR, GPx) in freshwater clams (Corbicula fluminea) exposed during 14 days and correlated with metal(loid) environmental concentrations. Results pointed that enzymatic systems are activated to combat oxidative stress in just 24 h. Along exposure, there were homeostatic regulations with the glutathione activity that influenced in lipid peroxidation oscillations, provoking significant DNA strand damage after 14 exposure days. EROD activity showed no changes throughout the exposure period. The Asian clam displayed balance biomarkers of exposure-antioxidant activity under non-stressfully environments; meanwhile, when was introduced into acid polymetallic environments, such as the acid mine drainage, its enzymatic activity was displaced towards biomarkers of effect and the corresponding antioxidant activity.
采用结合分析生物标志物（淡水贻贝中 DNA 链断裂、LPO、EROD、GST、GR、GPx）的方法，评估了伊比利亚黄铁矿带（西班牙西南部）酸性矿山排水污染河流（奥德亚尔河）的环境质量，这些贻贝在 14 天的暴露过程中受到了污染。生物标志物分析结果与金属（类）环境浓度相关。结果表明，酶系统在 24 小时内被激活以对抗氧化应激。随着暴露时间的延长，谷胱甘肽的活性发生了动态变化，影响了脂质过氧化反应的波动，在 14 天的暴露后引发了显著的 DNA 链断裂。整个暴露期间，EROD 活性没有变化。亚洲贻贝在非胁迫环境下表现出暴露-抗氧化活性的平衡生物标志物；然而，当引入酸性多金属环境，如酸性矿山排水时，其酶活性会向效应生物标志物和相应的抗氧化活性转移。
