1.5T下简化体素内不相干运动（IVIM）分析在恶性肝脏病变和肝实质常规临床扩散加权成像中的短期测量重复性
Short-Term Measurement Repeatability of a Simplified Intravoxel Incoherent Motion (IVIM) Analysis for Routine Clinical Diffusion-Weighted Imaging in Malignant Liver Lesions and Liver Parenchyma at 1.5 T.
作者信息
Pieper Claus Christian, Sprinkart Alois Martin, Kukuk Guido Mattias, Mürtz Petra
机构信息
Radiology, University-Hospital Bonn, Germany.
出版信息
Rofo. 2019 Mar;191(3):199-208. doi: 10.1055/a-0649-1205. Epub 2018 Aug 6.
OBJECTIVES
To evaluate measurement repeatability of parameters derived from simplified intravoxel incoherent motion (IVIM) analysis of diffusion-weighted imaging (DWI) using 3 b-values.
MATERIALS AND METHODS
24 patients (16 male, 8 female, mean age: 67 years) with hepatic malignancy (HCC: 10, metastases: 14) underwent 29 liver MRI examinations at 1.5 T. Respiratory-triggered DWI (b = 0, 50, 800 s/mm) was acquired twice. Parameter maps of the apparent diffusion coefficient ADC(0,800), estimated diffusion coefficient D' and perfusion fraction f' were calculated. Measurement repeatability for a region of interest (ROI) placed in one lesion and liver parenchyma per lobe was assessed by intra-session variation coefficients (CV).
RESULTS
86 ROIs (43 lesions, 43 parenchymas) were analyzed. Parameters did not significantly differ between measurements. Repeatability was excellent for ADC(0,800) and D' and good for f' in parenchyma (CVs: 7.3 %, 9.8 %, 13.0 %) and lesions (CVs: 7.5 %, 8.5 %, 11.0 %). Differences in CV-values between liver and lesions were not significant. Repeatability was better for the right than for the left lobe by tendency, for parenchyma (CVs: 6.4 % vs 8.4 %, 8.8 % vs 10.9 %, 10.5 % vs 16.0 %) and for lesions (CVs: 6.9 % vs 8.1 %, 7.5 % vs 9.5 %, 9.5 % vs 12.7 %).
CONCLUSION
Measurement repeatability is excellent for ADC(0,800) and D' values and good for f' values using the simplified IVIM approach, both in lesions and liver parenchyma. Repeatability was better for lesions in the right compared to the left liver lobe.
KEY POINTS
· Repeatability obtained by a simplified IVIM analysis approach is good to excellent.. · Repeatability is better for the right than for the left liver lobe.. · The simplified approach may be helpful in diagnosing and monitoring liver malignancies..
CITATION FORMAT
· Pieper CC, Sprinkart AM, Kukuk GM et al. Short-Term Measurement Repeatability of a Simplified Intravoxel Incoherent Motion (IVIM) Analysis for Routine Clinical Diffusion-Weighted Imaging in Malignant Liver Lesions and Liver Parenchyma at 1.5T. Fortschr Röntgenstr 2019; 191: 199 - 208.
目的
使用3个b值评估扩散加权成像（DWI）简化体素内不相干运动（IVIM）分析得出的参数测量重复性。
材料与方法
24例（16例男性，8例女性，平均年龄：67岁）肝脏恶性肿瘤患者（肝细胞癌：10例，转移瘤：14例）在1.5T条件下接受了29次肝脏MRI检查。呼吸触发DWI（b = 0、50、800 s/mm²）采集两次。计算表观扩散系数ADC(0,800)、估计扩散系数D'和灌注分数f'的参数图。通过组内变异系数（CV）评估置于每个叶的一个病变和肝实质中的感兴趣区（ROI）的测量重复性。
结果
分析了86个ROI（43个病变，43个肝实质）。测量之间参数无显著差异。肝实质（CV：7.3%、9.8%、13.0%）和病变（CV：7.5%、8.5%、11.0%）中ADC(0,800)和D'的重复性极佳，f'的重复性良好。肝脏和病变之间CV值的差异不显著。右叶的重复性在趋势上优于左叶，肝实质（CV：6.4%对8.4%，8.8%对10.9%，10.5%对16.0%）和病变（CV：6.9%对8.1%，7.5%对9.5%，9.5%对12.7%）。
结论
使用简化IVIM方法，病变和肝实质中ADC(0,800)和D'值的测量重复性极佳，f'值的重复性良好。右肝叶病变的重复性优于左肝叶。
关键点
· 简化IVIM分析方法获得的重复性良好至极佳。· 右肝叶的重复性优于左肝叶。· 简化方法可能有助于肝脏恶性肿瘤的诊断和监测。
引用格式
· Pieper CC, Sprinkart AM, Kukuk GM等。1.5T下恶性肝病变和肝实质常规临床扩散加权成像简化体素内不相干运动（IVIM）分析的短期测量重复性。Fortschr Röntgenstr 2019; 191: 199 - 208。
Zotero 插件