胆囊收缩素在促肾上腺皮质激素释放中的作用：与血管加压素和促肾上腺皮质激素释放因子在大鼠下丘脑室旁核细胞中共存。

Role of cholecystokinin in corticotropin release: coexistence with vasopressin and corticotropin-releasing factor in cells of the rat hypothalamic paraventricular nucleus.

作者信息

Mezey E, Reisine T D, Skirboll L, Beinfeld M, Kiss J Z

出版信息

Proc Natl Acad Sci U S A. 1986 May;83(10):3510-2. doi: 10.1073/pnas.83.10.3510.

DOI:10.1073/pnas.83.10.3510

PMID:3010303

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC323546/

Abstract

Cholecystokinin-8 (CCK8)-containing cell bodies in the parvocellular region of the rat paraventricular nucleus (PVN) contain vasopressin and corticotropin-releasing factor (CRF). The CCK8 and vasopressin in these cells can readily be visualized in adrenalectomized, but not in shamoperated animals. Furthermore, CCK8 levels as measured by RIA change in the PVN and in the median eminence in response to adrenalectomy. CCK8 has a stimulatory effect on corticotropin (ACTH) release from primary cultures of the anterior pituitary. This stimulation is additive with that produced by vasopressin; CCK8 plus vasopressin have an effect as great as CRF in stimulating ACTH release. Our results suggest that CCK8 may participate in the regulation of ACTH release under certain physiological conditions.

摘要

大鼠室旁核（PVN）小细胞区含胆囊收缩素-8（CCK8）的细胞体含有血管加压素和促肾上腺皮质激素释放因子（CRF）。这些细胞中的CCK8和血管加压素在肾上腺切除的动物中很容易被观察到，但在假手术动物中则不然。此外，通过放射免疫分析测定，PVN和正中隆起中的CCK8水平会因肾上腺切除而发生变化。CCK8对垂体前叶原代培养物中促肾上腺皮质激素（ACTH）的释放有刺激作用。这种刺激与血管加压素产生的刺激相加；CCK8加血管加压素在刺激ACTH释放方面的作用与CRF一样大。我们的结果表明，CCK8可能在某些生理条件下参与ACTH释放的调节。