复发缓解型多发性硬化症成人结构化体育锻炼干预的可行性和效果：一项初步研究。
Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study.
机构信息
Department of Physiological Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
Department of Neurology, Bellvitge University Hospital, Barcelona, Spain.
出版信息
J Sports Sci Med. 2018 Aug 14;17(3):426-436. eCollection 2018 Sep.
Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.
多发性硬化症（MS）是一种慢性神经系统疾病，影响年轻人在个人、职业和社会成长的高峰期。最近的体力活动指南确定，运动是轻度或中度残疾的 MS 患者临床管理的重要组成部分。本研究的主要目的是测试两种不同的 40 周结构化体育锻炼干预（监督高强度间歇训练加家庭锻炼计划和自我应用家庭为基础的锻炼计划）对临床演变、心理健康、生活质量、疲劳、心肺功能、力量和平衡的可行性和效果患有 MS 的人。29 名复发缓解型多发性硬化症（RRMS）患者参加了这项研究。他们都是完全可走动的，且残疾程度最小（扩展残疾状况量表<3），至少在过去六个月内是这样。参与者选择参加面对面加家庭锻炼组（CFTFG；n=8）、自我应用家庭锻炼组（HG；n=11）或对照组（CG；n=10）。共有 23 名参与者完成了方案（79.3%），其中 CFTFG 有 8 名参与者（100%）、HG 有 7 名参与者（63.6%）和 CG 有 8 名参与者（80%）。在训练的前 20 周，CFTFG 的依从率达到 77.5%，HG 的依从率达到 50%。在训练的后 20 周，CFTFG 的依从率达到 62.5%，HG 的依从率达到 45.4%。经过 20 周的训练，CFTFG 的绝对 VO 峰值和 30 秒坐站测试显著改善（均<0.05）。这项研究证实，为一组完全可走动和轻度残疾的 RRMS 患者提供 40 周结构化锻炼计划是可行且安全的。任何与试验相关的不良事件均由参与者报告。
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