Preston Chet, Kasoff Willard S, Witte Russell S
Department of Biomedical Engineering, University of Arizona, Tucson, Arizona, USA.
Department of Surgery, University of Arizona, Tucson, Arizona, USA.
Ultrasound Med Biol. 2018 Nov;44(11):2345-2357. doi: 10.1016/j.ultrasmedbio.2018.06.021. Epub 2018 Aug 14.
We describe a new application of acoustoelectric imaging for non-invasive mapping of the location, magnitude and polarity of current generated by a clinical deep brain stimulation (DBS) device. Ultrasound at 1MHz was focused near the DBS device as short current pulses were injected across different DBS leads. A recording electrode detected the high-frequency acoustoelectric interaction signal. Linear scans of the US beam produced time-varying images of the magnitude and polarity of the induced current, enabling precise localization of the DBS leads within 0.70mm, a detection threshold of 1.75mA at 1 MPa and a sensitivity of 0.52 ± 0.07 μV/(mAMPa). Monopole and dipole configurations in saline were repeated through a human skullcap. Despite 13.8-dB ultrasound attenuation through bone, acoustoelectric imaging was still >10dB above background with a sensitivity of 0.56 ± 0.10 μV/(mAMPa). This proof-of-concept study indicates that selective mapping of lead currents through a DBS device may be possible using non-invasive acoustoelectric imaging.
我们描述了声电成像的一种新应用，用于对临床深部脑刺激（DBS）设备产生的电流的位置、大小和极性进行无创映射。当在不同的DBS电极导线间注入短电流脉冲时，将1MHz的超声波聚焦在DBS设备附近。一个记录电极检测高频声电相互作用信号。超声束的线性扫描产生了感应电流大小和极性随时间变化的图像，能够在0.70mm范围内精确定位DBS电极导线，在1MPa时检测阈值为1.75mA，灵敏度为0.52±0.07μV/(mAMPa)。通过人类头盖骨在盐水中重复进行单极和偶极配置实验。尽管超声波通过骨骼有13.8dB的衰减，但声电成像仍比背景高>10dB，灵敏度为0.56±0.10μV/(mAMPa)。这项概念验证研究表明，使用无创声电成像可能对通过DBS设备的电极导线电流进行选择性映射。
