IEEE Trans Biomed Eng. 2018 Nov;65(11):2392-2404. doi: 10.1109/TBME.2018.2866332. Epub 2018 Aug 20.
We propose a calibration-free method and system for cuffless blood pressure (BP) measurement from superficial arteries. A prototype device with bi-modal probe arrangement was designed and developed to estimate carotid BP - an indicator of central aortic pressure.
Mathematical models relating BP parameters of an arterial segment to its dimensions and local pulse wave velocity (PWV) are introduced. A bi-modal probe utilizing ultrasound and photoplethysmograph sensors was developed and used to measure diameter values and local PWV from the carotid artery. Carotid BP was estimated using the measured physiological parameters without any subject- or population-specific calibration procedures. The proposed cuffless BP estimation method and system were tested for accuracy, usability, and for potential utility in hypertension screening, on a total of 83 subjects.
The prototype device demonstrated its capability of detecting beat-by-beat arterial dimensions and local PWV simultaneously. Carotid diastolic BP (DBP) and systolic BP (SBP) were estimated over multiple cardiac cycles in real-time. The absolute error in carotid DBP was <10 mmHg in 82% cases, and root-mean-square-error = 8.3 mmHg. Consistent with the theory, estimated SBP at the carotid site was lower than the reference brachial SBP. ROC curves obtained for hypertension screening analysis revealed an area under the curve ≥0.8 for both carotid SBP and DBP values, illustrating the potential for using the developed method in hypertension screening.
The feasibility of calibration-free, cuffless BP measurement at an arterial site of interest was demonstrated with a level of acceptable accuracy. The study also demonstrated the potential utility of the proposed method and system in hypertension screening and local evaluation of arterial stiffness indices.
Novel approach for calibration-free cuffless BP estimation; a potential tool for local BP measurement and hypertension screening.
我们提出了一种从浅表动脉进行无袖带血压（BP）测量的校准方法和系统。设计并开发了一种具有双模探头布置的原型设备，以估计颈动脉 BP - 主动脉压力的指标。
引入了将动脉段的 BP 参数与其尺寸和局部脉搏波速度（PWV）相关联的数学模型。开发了一种利用超声和光体积描记传感器的双模探头，用于从颈动脉测量直径值和局部 PWV。使用所测量的生理参数而无需任何受试者或人群特定的校准程序来估计颈动脉 BP。在总共 83 名受试者中，对无袖带 BP 估计方法和系统进行了准确性、可用性以及在高血压筛查中的潜在应用的测试。
原型设备展示了其同时检测动脉尺寸和局部 PWV 的能力。实时实时估计多个心动周期中的颈动脉舒张压（DBP）和收缩压（SBP）。在 82％的情况下，颈动脉 DBP 的绝对误差<10mmHg，均方根误差= 8.3mmHg。与理论一致，估计的颈动脉部位 SBP 低于参考肱动脉 SBP。用于高血压筛查分析的 ROC 曲线显示，颈动脉 SBP 和 DBP 值的曲线下面积均≥0.8，表明该方法在高血压筛查中的应用潜力。
证明了在感兴趣的动脉部位进行无袖带 BP 测量的免校准可行性，且具有可接受的准确性水平。该研究还证明了所提出的方法和系统在高血压筛查和局部评估动脉僵硬指数中的潜在应用。
无袖带 BP 估计的新方法；局部 BP 测量和高血压筛查的潜在工具。
