Foster C S, Tsai Y, Monroe J G, Campbell R, Cestari M, Wetzig R, Knipe D, Greene M I
Clin Immunol Immunopathol. 1986 Aug;40(2):313-25. doi: 10.1016/0090-1229(86)90036-x.
We studied the influence of lgh-linked genes on the development of keratopathy after corneal inoculation with herpes simplex virus (HSV). Using congenic strains of mice, we found that the lgh-1 gene locus, or genes closely linked to it, influence the clinical expression of HSV infection. Mice with the lgh-1e or lgh-1d allotype routinely developed severe keratopathy after HSV corneal inoculation, whereas congenic strains with lgh-1a or lgh-1b allotype were less susceptible. Cell-mediated immune responses to HSV also differed between susceptible and resistant murine strains. We interpret our results to imply a genetic influence on cell-mediated, acquired immune responses to HSV infection.
我们研究了与lgh相关的基因对单纯疱疹病毒（HSV）角膜接种后角膜病变发展的影响。利用小鼠的同源近交系，我们发现lgh-1基因座或与之紧密连锁的基因会影响HSV感染的临床表现。具有lgh-1e或lgh-1d同种异型的小鼠在HSV角膜接种后通常会发生严重的角膜病变，而具有lgh-1a或lgh-1b同种异型的同源近交系则较不易感。对HSV的细胞介导免疫反应在易感和抗性小鼠品系之间也有所不同。我们对结果的解释是，基因对HSV感染的细胞介导的获得性免疫反应有影响。
