Morse Daniel C, Tschen Jaime A, Silapunt Sirunya
University of Texas McGovern Medical School at Houston, Houston, Texas.
Dermatol Online J. 2018 Jun 15;24(6):13030/qt45h896p8.
Dermatofibroma frequently presents as a red-brown nodule on the extremities of the middle aged. Atrophic dermatofibroma is a rare variant that has been most commonly described as an atrophic depressed, erythematous lesion in females. The correct diagnosis of atrophic dermatofibroma is often hindered by its infrequent presentation. It has a female preponderance with an occurrence ratio of 10:1. We describe a case of an atrophic dermatofibroma on the back of an elderly man. Skin biopsy demonstrated a spindle cell proliferation in a storiform pattern, loss of elastic fibers, and substantial atrophy of both the underlying dermis and subcutaneous tissue. An aggregation of elastic fibers was found in the periphery of the tumor. These histologic features supported the diagnosis of atrophic dermatofibroma. The dermal and adipocyte atrophy was likely responsible for the retracted appearance of the lesion.
皮肤纤维瘤常表现为中年患者四肢出现的红棕色结节。萎缩性皮肤纤维瘤是一种罕见的变异型,最常见的描述是女性身上出现的萎缩性凹陷、红斑性损害。萎缩性皮肤纤维瘤因其罕见的表现,常常难以做出正确诊断。它在女性中更为常见,男女发病比例为10:1。我们报告一例老年男性背部的萎缩性皮肤纤维瘤病例。皮肤活检显示梭形细胞呈束状排列增殖,弹性纤维缺失,其下方真皮层和皮下组织明显萎缩。在肿瘤周边发现弹性纤维聚集。这些组织学特征支持萎缩性皮肤纤维瘤的诊断。真皮层和脂肪细胞萎缩可能是导致病变出现回缩外观的原因。