来自益母草的新二萜莱菔素 G-L。
New diterpenes leojaponins G-L from Leonurus japonicus.
机构信息
Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan.
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
出版信息
Fitoterapia. 2018 Oct;130:125-133. doi: 10.1016/j.fitote.2018.08.014. Epub 2018 Aug 24.
Six new diterpenes, leojaponins G-L (1-6) along with 19 known compounds (7-25) were isolated from Leonurus japonicus. Their structures were elucidated by NMR, MS, IR, UV, and ECD spectroscopic data. Anti-melanogenesis assay indicated that 7 could safely and dose-dependently decrease melanin production in B16F10 melanoma cell with an IC value of 59.1 μM, but moderately inhibit tyrosinase activity. Without cytotoxicities at 20 μM, compounds 11, 14, 15, and 17-21 showed significant melanogenesis stimulation activities at the percentages of 7.7-48.2. Antioxidants 19 and 24 could notably inhibit ROS production in a dose-dependent manner with percentages of 24.7-42.2 and 27.9-40.2, respectively among the concentrations of 0.16 to 100 μM. Our results demonstrated L. japonicus and its constituents could be potential botanical resources of cosmeceutical development for treatment and prevention of skin disorders.
从益母草中分离得到了 6 个新的二萜类化合物，即莱菔素 G-L（1-6），以及 19 个已知化合物（7-25）。通过 NMR、MS、IR、UV 和 ECD 光谱数据阐明了它们的结构。抗黑色素生成试验表明，化合物 7 能安全且剂量依赖性地降低 B16F10 黑素瘤细胞中黑色素的生成，IC 值为 59.1 μM，但对酪氨酸酶活性的抑制作用中等。在 20 μM 时无细胞毒性，化合物 11、14、15 和 17-21 在 7.7-48.2%的百分率下表现出显著的黑色素生成刺激活性。抗氧化剂 19 和 24 能以剂量依赖性的方式显著抑制 ROS 的产生，在 0.16 至 100 μM 的浓度范围内，分别为 24.7-42.2%和 27.9-40.2%。我们的研究结果表明，益母草及其成分可能是治疗和预防皮肤疾病的化妆品开发的潜在植物资源。
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