邦巴里病毒的发现进一步支持了蝙蝠作为埃博拉病毒宿主的说法。
The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses.
机构信息
One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA.
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
出版信息
Nat Microbiol. 2018 Oct;3(10):1084-1089. doi: 10.1038/s41564-018-0227-2. Epub 2018 Aug 27.
Abstract
Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans.
摘要
我们在此描述了一种新的埃博拉病毒——邦巴利病毒（BOMV）的完整基因组，该病毒在塞拉利昂的自由长尾蝙蝠（小自由长尾蝙蝠（Chaerephon pumilus）和安哥拉自由长尾蝙蝠（Mops condylurus））中被检测到。这些蝙蝠被发现栖息在房屋内，这表明存在人际传播的可能性。我们表明，病毒糖蛋白能够介导进入人体细胞。然而，需要进一步的研究来调查是否已经发生了暴露，或者 BOMV 是否对人类具有致病性。
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