Ozkan Ekrem, Crick Colin C, Taylor Alaric, Allan Elaine, Parkin Ivan P
Materials Chemistry Research Centre , Department of Chemistry , University College London , 20 Gordon St , London , WC1H 0AJ , UK . Email:
Department of Chemistry , Imperial College London , South Kensington Campus , London , SW7 2AZ , UK.
Chem Sci. 2016 Aug 1;7(8):5126-5131. doi: 10.1039/c6sc01150k. Epub 2016 Apr 20.
The adhesion and proliferation of bacteria on solid surfaces presents a major challenge in both healthcare and industrial applications. In response to this problem, an effective and simple method is reported to fabricate superhydrophobic antibacterial copper coated polymer films aerosol assisted chemical vapor deposition (AACVD). The material is characterized using a range of techniques including electron microscopy, water contact angle measurement and elemental mapping. The antibacterial activity of the modified film is tested against the Gram-negative bacterium, , and the Gram-positive bacterium, and the film shows highly significant antibacterial activity against both bacteria (>4 log reduction in bacterial numbers) in 15 min and 60 min, respectively. In addition, all the CVD modified samples results in a significant reduction in bacterial cell adhesion compared to the control materials. Thus, we report a new film type that has dual mode of action-the superhydrophobicity helps limit cell adhesion combined with a cytotoxic copper induced bacteria kill.
细菌在固体表面的粘附和增殖在医疗保健和工业应用中都构成了重大挑战。针对这一问题,报道了一种有效且简单的方法,即通过气溶胶辅助化学气相沉积(AACVD)制备超疏水抗菌铜涂层聚合物薄膜。使用一系列技术对该材料进行表征,包括电子显微镜、水接触角测量和元素映射。测试了改性薄膜对革兰氏阴性菌和革兰氏阳性菌的抗菌活性,该薄膜分别在15分钟和60分钟内对两种细菌均表现出高度显著的抗菌活性(细菌数量减少>4个对数级)。此外,与对照材料相比,所有化学气相沉积改性样品均导致细菌细胞粘附显著减少。因此,我们报道了一种具有双重作用模式的新型薄膜——超疏水性有助于限制细胞粘附,同时细胞毒性铜可杀死细菌。