Ikeuchi Miho, Asahina Ryota, Nishida Hidetaka, Kamishina Hiroaki, Kitoh Katsuya, Sakai Hiroki, Maeda Sadatoshi
Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Vet Dermatol. 2018 Dec;29(6):517-e172. doi: 10.1111/vde.12650. Epub 2018 Aug 30.
In canine epitheliotropic cutaneous T-cell lymphoma (ECTCL), neoplastic cells cause skin lesions and potentially metastasize to lymph nodes, blood and other organs. Murine models are potentially valuable for elucidating the molecular mechanisms responsible for regulation of ECTCL cell migration.
HYPOTHESIS/OBJECTIVES: To describe a phenotype of mice xenografted with canine ECTCL cells (EO-1 cells).
Four NOD.CB17-Prkdc /J (NOD SCID) mice were used.
EO-1 cells were subcutaneously xenografted into NOD SCID mice. After four weeks, the development of tumour lesions in skin and other organs was investigated.
Mice developed skin lesions with metastasis to the lymph nodes, spleen, lung, blood and liver.
Mice xenografted with EO-1 cells may be useful for studying the pathogenesis of canine ECTCL.
在犬皮肤嗜上皮性T细胞淋巴瘤（ECTCL）中，肿瘤细胞会引发皮肤病变，并可能转移至淋巴结、血液及其他器官。小鼠模型对于阐明ECTCL细胞迁移调控的分子机制具有潜在价值。
假设/目的：描述用犬ECTCL细胞（EO-1细胞）异种移植的小鼠的表型。
使用了4只NOD.CB17-Prkdc /J（NOD SCID）小鼠。
将EO-1细胞皮下异种移植到NOD SCID小鼠体内。四周后，研究皮肤和其他器官肿瘤病变的发展情况。
小鼠出现皮肤病变，并转移至淋巴结、脾脏、肺、血液和肝脏。
用EO-1细胞异种移植的小鼠可能有助于研究犬ECTCL的发病机制。
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