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胸椎反复手术导致的中枢神经系统浅表性铁沉积症:1例罕见病例

Superficial Siderosis of the Central Nervous System Due to Recurrent Surgeries of the Thoracic Spine: A Rare Case.

作者信息

Camlar Mahmut, Karadag Ali, Oztekin Ozgur, Ozer Fusun

机构信息

Department of Neurosurgery, Tepecik Research and Training Hospital, University of Health Sciences, Izmir, Turkey.

Department of Neurosurgery, Tepecik Research and Training Hospital, University of Health Sciences, Izmir, Turkey.

出版信息

World Neurosurg. 2018 Nov;119:384-388. doi: 10.1016/j.wneu.2018.08.140. Epub 2018 Aug 27.

DOI:10.1016/j.wneu.2018.08.140
PMID:30165218
Abstract

BACKGROUND

Superficial siderosis (SS) of the central nervous system is a rare condition caused by hemosiderin deposition in the subpial layers of the brain and spinal cord. Surgical complications are the primary factor for occurrence of secondary SS. We present a case of SS with an identified bleeding origin in the thoracic spine.

CASE DESCRIPTION

A 58-year-old female patient experienced 9 months of continuous progressive dizziness, difficulty with mobilization, drop attacks, and lack of hearing. The patient also had an extensive history of thoracic spinal surgeries. She came to the hospital with gait imbalance. Gradient echo (GE) magnetic resonance imaging (MRI) confirmed hemosiderin deposition along the cerebellar folia and vermis. GE sequences are preferable in this diagnosis, because of higher sensitivity, and for detecting characteristic T2 hypointensity. The dural defect was repaired with an artificial dural patch in thoracal operation area. Clinical findings, imaging studies, intraoperative findings, and literature information are presented.

CONCLUSIONS

Performance of an open neurosurgical procedure to repair a dural defect in the presence of MRI confirmed that superficial siderosis is an optimal method and a crucial step to ensure the safe resolution of the condition and to break the circle of emergency admissions of a patient with a dural defect and a history of multiple spinal surgeries.

摘要

背景

中枢神经系统表面铁沉积症(SS)是一种罕见疾病,由含铁血黄素沉积于脑和脊髓的软膜下层所致。手术并发症是继发性SS发生的主要因素。我们报告一例在胸椎发现出血源的SS病例。

病例描述

一名58岁女性患者持续渐进性头晕9个月,活动困难,发作性跌倒,听力减退。该患者有广泛的胸椎手术史。她因步态不稳前来就诊。梯度回波(GE)磁共振成像(MRI)证实沿小脑叶片和蚓部有含铁血黄素沉积。由于更高的敏感性以及用于检测特征性T2低信号,GE序列在该诊断中更可取。在胸椎手术区域用人造硬脑膜补片修复硬脑膜缺损。展示了临床发现、影像学研究、术中发现及文献资料。

结论

在MRI证实存在硬脑膜缺损的情况下进行开放性神经外科手术修复,表明这是确保安全解决该病症以及打破有硬脑膜缺损和多次脊柱手术史患者紧急入院循环的最佳方法和关键步骤。

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