住院时间和生育费用：不孕和 ART 的影响。
Length of stay and cost of birth hospitalization: effects of subfertility and ART.
机构信息
Department of Pediatrics, Oregon Health and Science University, Portland, USA.
Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, USA.
出版信息
J Perinatol. 2018 Nov;38(11):1457-1465. doi: 10.1038/s41372-018-0205-9. Epub 2018 Aug 30.
OBJECTIVE
The objective of this study is to measure delivery length of stay (LOS) and cost as proxies for infant morbidity in assisted reproductive technology (ART) and subfertile deliveries.
STUDY DESIGN
Massachusetts singleton births, ≥ 23 weeks gestational age (GA) between 2004 and 2010, were linked with ART data, vital records, and hospital discharges. LOS and costs (2010 US dollars) of infants born to fertile (no ART or indicators of infertility), subfertile (indicators of infertility but no ART), and ART-treated (linked to ART data) deliveries were compared. Least-square means and SE were calculated.
RESULTS
Of 345,756 singletons (fertile n = 332,481, subfertile n = 4987, and ART-treated n = 8288), overall LOS was 3.79 ± 0.01, 4.32 ± 0.15, and 4.90 ± 0.04 days, and costs were $2980 ± 6, $3217 ± 58, and $4483 ± 62, respectively. GA and birthweight predicted much of the intergroup difference.
CONCLUSION
Maternal fertility group was not an independent predictor of infant LOS and costs. Prematurity and birthweight were driving factors in resource utilization.
目的
本研究旨在通过测量分娩住院时间（LOS）和成本，来评估辅助生殖技术（ART）和不孕分娩的婴儿发病率。
研究设计
2004 年至 2010 年，马萨诸塞州≥23 周龄（GA）的单胎活产与 ART 数据、生命记录和住院记录相关联。比较了由生育力正常（无 ART 或不孕指标）、生育力低下（有不孕指标但无 ART）和接受 ART 治疗（与 ART 数据相关联）分娩的婴儿的 LOS 和成本（2010 年美元）。计算了最小二乘均值和 SE。
结果
在 345756 例单胎（生育力正常 n=332481 例，生育力低下 n=4987 例，ART 治疗 n=8288 例）中，总体 LOS 分别为 3.79±0.01、4.32±0.15 和 4.90±0.04 天，成本分别为 2980±6 美元、3217±58 美元和 4483±62 美元。GA 和出生体重预测了大部分组间差异。
结论
母体生育力组并不是婴儿 LOS 和成本的独立预测因素。早产和出生体重是资源利用的驱动因素。
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